Pharmaceutical
Preformulation
Preformulation
Preformulation involves the
application of biopharmaceutical principles to the physicochemical parameters
of drug substance are characterized with the goal of designing optimum drug
delivery system.
application of biopharmaceutical principles to the physicochemical parameters
of drug substance are characterized with the goal of designing optimum drug
delivery system.
Before beginning the formal preformulation programs the preformulation
scientist must consider the following factors:-
scientist must consider the following factors:-
– The amount of drug available.
– The physicochemical properties of
the drug already known.
the drug already known.
– Therapeutic category and
anticipated dose of compound.
anticipated dose of compound.
– The nature of information, a
formulation should have or would like to have.
formulation should have or would like to have.
