Project report on Trans-dermal Drug Delivery Systems

Project Report on Trans-dermal Drug Delivery Systems

Project report on Trans-dermal Drug Delivery Systems for Pharmaceutical Students which covers all details of TDDS.

CONTENTS

1. Introduction

• Advantages

• Limitations of TDD

2. Rising interest in transdermal vaccines

3. Classification for TDDS

• Matrix patches

• Liquid reservoir patches

4. Generation of TDDS

• First generation TDDS

i) Transdermal patch

ii) Transdermal patch design

iii) Stages in Drug Delivery in a Transdermal Patch

• Second generation TDDS

i) Non-cavitational ultrasound

• Third generation TDDS

i) Combinations of chemical enhancers

ii) Biochemical enhancers

iii) Electroporation

iv) Cavitational ultrasound

v) Microneedles

vi) Thermal ablation

vii) Microdermabrasion

viii) Conventional chemical enhancers

5. Representative transdermal drugs in clinical development

6. Human skin

• Percutaneous Absorption

• Transepidermal absorption

• Transfollicular (shunt pathway) absorption

7. Drug penetration

• Routes of drug penetration

• Macro route

• Microroute

• Factor affecting drug penetration

i) Physicochemical properties of the penetrants

ii) Physicochemical properties of drug delivery system

iii) Physiological and pathological conditions of the skin

8. Clearance by local circulation

9. Kinetics of Transdermal Permeation

10. Basic component of TDDS

• Backing Films

• Release Liners

• Pressure-Sensitive Adhesive

• Penetration Enhancers

• Micro porous or Semi-Permeable Membranes

• Pouching Materials

11. Ideal drug candidates for TDDS

12. Designing of TDDS

13. Iontophoresis

• Ideal drug candidates for iontophoresis

• Reverse iontophoresis

14. Future outlook of TDDS

• Microfabricated Microneedle

• Energy Induced

i) Laser Assisted TDDS

ii) Direct Heat Induced Microporation

15. Transdermal product

16. Supersaturated system/crystal reservoir technology

• Sustained Release

• Burst Release

• Chrono-Controlled Release

17. Radiofrequency-driven skin microchonneling

• Transferosomes

18. Approaches used in development of TDDS

• Matrix Systems

• Reservoir Systems

• Micro-Reservoir Systems

19. Production of Transdermal Drug Delivery Systems

• Membrane Permeation Controlled Systems

• Adhesive Dispersion Type Systems

• Matrix Dispersion Type Systems

• Micro-Reservoir Systems

20. Effect Production of Transdermal Drug Delivery Systemsect of hydrophobic permeation enhancer in matrix type TDDS

21. Experiment

• Material

• Preparation of Monolithic Matrix Film

• In vitro Drug Release Study

• Skin Permeation Study

• Results and Discussion

• Skin Permeation

22. Advanced technique for penetration enhanced in TDDS

23. Conclusion

24. References

Project Report on Trans-dermal Drug Delivery Systems