Novel Drug Delivery Systems (NDDS) – B. Pharma 7th Semester Complete PDF Notes

Novel Drug Delivery Systems (NDDS) – B. Pharma 7th Semester Complete PDF Notes

Novel Drug Delivery Systems 7th semester notes

Scope: These Novel Drug Delivery Systems (NDDS) are designed to impart basic knowledge in the area of novel drug delivery systems.

Objectives: Upon completion of the course student shall be able

1. To understand various approaches for the development of novel drug delivery systems.

2. To understand the criteria for the selection of drugs and polymers for the development of Novel drug delivery systems, their formulation, and evaluation

Novel Drug Delivery Systems (NDDS) Course content:

Novel Drug Delivery Systems (NDDS) Unit-I    

Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design controlled release formulations based on diffusion, dissolution, and ion exchange & pH Control principles. Physicochemical and biological properties of drugs relevant to controlled release formulations

Sustained and Controlled  Release

Model of Oral Drug Delivery

Factors to be considered in the design of controlled release dosage form

Polymers: Introduction, classification, properties, advantages and application of polymers in the formulation of controlled release drug delivery systems.

Novel Drug Delivery Systems (NDDS) Unit-II  

Microencapsulation: Definition, advantages and disadvantages, microspheres/microcapsules, microparticles, methods of microencapsulation, applications

Mucosal Drug Delivery System: Introduction, Principles of bio adhesion/mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, the concept of implants and osmotic pump

Novel Drug Delivery Systems (NDDS) Unit-III        

Transdermal Drug Delivery Systems: Introduction, Permeation through the skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches

Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high-density systems, inflatable and gastro adhesive systems, and their applications, gastroretentive dds models

Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

Novel Drug Delivery Systems (NDDS) Unit-IV

Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies, and their applications

Novel Drug Delivery Systems (NDDS) Unit-V 

Ocular Drug Delivery Systems: Introduction, intra ocular barriers, and methods to overcome –Preliminary study, ocular formulations, and concerts

Intrauterine Drug Delivery Systems: Introduction, Advantages and Disadvantages, development of intrauterine devices (IUDs) and Applications

Novel Drug Delivery System Notes 7th Sem

Novel Drug Delivery Systems Short Notes: Revolutionizing Drug Delivery

Novel drug delivery systems (NDDS) are innovative approaches that aim to enhance the efficacy, safety, and convenience of drug delivery. These systems focus on optimizing the release, targeting, and absorption of therapeutic agents within the body. By incorporating advanced technologies and materials, NDDS offers significant advantages over traditional drug delivery methods. Let’s explore some key aspects of novel drug delivery systems.

1. Controlled Release Systems: Controlled release systems allow for the sustained and controlled release of drugs over an extended period. They ensure a constant therapeutic concentration in the body, reducing the frequency of dosing and minimizing side effects. Examples include transdermal patches, implantable devices, and oral controlled-release formulations.

2. Targeted Drug Delivery: Targeted drug delivery systems aim to deliver drugs specifically to the desired site of action, minimizing systemic exposure and reducing adverse effects. These systems employ various strategies, such as nanoparticles, liposomes, and antibody-drug conjugates, to selectively target specific cells, tissues, or organs.

3. Nanotechnology-Based Systems: Nanotechnology has revolutionized drug delivery by enabling the design and development of nano-sized carriers for drugs. Nanoparticles, liposomes, micelles, and dendrimers offer improved drug solubility, enhanced bioavailability, prolonged circulation time, and enhanced cellular uptake.

4. Implantable Drug Delivery Systems: Implantable devices are designed to deliver drugs directly into the body for a prolonged period. These systems can be placed under the skin or within specific organs to provide continuous and controlled drug release. Implantable devices offer advantages such as reduced dosing frequency and improved patient compliance.

5. Inhalation and Pulmonary Delivery Systems: Inhalation and pulmonary drug delivery systems are used for the localized treatment of respiratory diseases and systemic delivery of drugs. Inhalers, nebulizers, and dry powder inhalers allow drugs to be directly delivered to the lungs, enabling rapid absorption and targeted action.

6. Stimuli-Responsive Systems: Stimuli-responsive drug delivery systems respond to specific triggers or environmental cues to release drugs. These systems utilize factors such as pH, temperature, light, enzymes, or magnetic fields to trigger drug release at the desired site, enhancing therapeutic efficacy and reducing side effects.

7. Gene and RNA-Based Delivery Systems: Novel drug delivery systems also include gene and RNA-based delivery systems for the targeted delivery of genetic material or RNA therapeutics. These systems protect genetic material from degradation and enable efficient delivery to specific cells or tissues for gene therapy or RNA interference.

8. 3D Printing-Based Systems: 3D printing has emerged as a powerful tool for personalized medicine and on-demand manufacturing of drug delivery systems. It enables the fabrication of complex and customized dosage forms with precise drug release profiles, offering personalized treatment options and dosage flexibility.

9. Combination Drug Delivery Systems: Combination drug delivery systems involve the simultaneous delivery of multiple drugs or therapeutic agents. These systems can enhance therapeutic outcomes by synergistic effects, targeted delivery, or sequential release of drugs, allowing for the treatment of complex diseases or multiple conditions.

10. Bioadhesive Systems: Bioadhesive drug delivery systems adhere to biological surfaces for localized drug delivery. These systems can be designed for mucosal, ocular, or transdermal drug delivery, providing prolonged contact time and enhanced drug absorption.

Novel Drug Delivery Systems (NDDS) Recommended Books: (Latest Editions)

1. Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.

2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992.

3. Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim

4. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edition 1997 (reprint in 2001).

5. S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances, Vallabh Prakashan, New Delhi, First edition 2002.

Novel Drug Delivery Systems (NDDS) Journals

1. Indian Journal of Pharmaceutical Sciences (IPA)

2. Indian Drugs (IDMA)

3. Journal of Controlled Release (Elsevier Sciences)

4. Drug Development and Industrial Pharmacy (Marcel & Decker)

5. International Journal of Pharmaceutics (Elsevier Sciences)

NDDS Notes 7th sem

Novel drug delivery system notes pdf

Novel drug delivery system notes 7th sem

Novel drug delivery system pdf

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