SOP on Cleaning of Colloid Mill

SOP
on Cleaning of Colloid Mill

 

 

Objective : To describe cleaning procedure for colloid mill.

 

Scope : To ensure that
the equipment is clean and free from any starting materials of previous batch
or product residues.

 

Responsibility : 1.It  is the responsibility of
operating staff to clean the equipment.

2. Production Chemist to ensure that
procedure is followed.

 

Materials &
Equipment :

1.     
Cleaning agent: Teepol or liquid soap.

2.     
Mops / brush / lint free cloth

 

Procedure

 

(1)  
Drain out the colloid mill for left covers.

(2)  
Fill the colloidal mill with 5 liters of boiled tap
water, run it for 5 minutes and drain the washings. Repeat the cleaning
procedure with another 5 liters of boiled tap water and again drain the
washings.

(3)  
Prepare a Teepol solution (10ml à 10 liters water)
or liquid-soap (50gm
à 5 liters water) and clean the surfaces by mopping.

(4)  
Wash the inner surfaces of colloid mill by running
tap water for 10 minutes and drain the washings. Repeat the procedure for
another 10 minutes and again drain the washings.

(5)  
Wash the inner surfaces of the colloid mill by using
10 liters of purified water for 10 minutes and drain the washings.

(6)  
Finally rinse the colloid mill with previously
boiled purified water and drain it completely.

(7)  
Send the wash water for analysis of residual active
ingredients of previous product.

(8)  
Let it dry in air, cover the equipment and put a
label “Cleaned” or “Ready for use”.

 

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