SOP on Fumigation of Manufacturing Areas
SOP on Fumigation of Manufacturing Areas
1.0 Purpose: This SOP describes a procedure for the fumigation in working areas.
2.0 Scope: A routine disinfection of the manufacturing areas keep the microbial load to an acceptance level.
3.0 Responsibility: Quality Control Microbiologist to ensure that the procedure is followed.
4.0 Materials and Equipment:
4.1 Potassium permanganate
4.2 Formalin solution
5.0 Procedure:
5.1 Pre-Fumigation Procedures
5.1.1 All materials, products and equipment that might be damaged or contaminated by formaldehyde should be removed from the room.
5.1.2 All the UV-lights should be switched off..
5.2 Steps to Begin Fumigation
5.2.1 Double-check that the area is sealed and all personnel have evacuated.
5.2.2 Install warning signs and barriers. Notify all relevant personnel that the area is under fumigation.
5.2.3 Activate the fogging machines and start the fumigation process.
5.2.4 Monitor the fumigant concentration levels using gas detection equipment.
5.2.5 Taking precautions, the operator should pour sufficient formaldehyde solution into the basin containing the required quantity of potassium permanganate (i.e. 1 part formaldehyde solution and 3 parts potassium permanganate).
5.2.6 Fumigation is best carried out immediately before the weekend.
5.3 Post-Fumigation Procedures
5.3.1 Once the fumigation period is complete, begin ventilating the area by opening windows and using exhaust fans. This process helps to dissipate any remaining fumigant gases.
5.3.2 After ventilation, use gas monitors to check the air quality. Ensure that fumigant levels have dropped to safe levels before allowing re-entry into the area.
5.3.3 Conduct a thorough inspection of the area to confirm that all fumigant has been cleared and that the environment is safe for personnel. Check for any residual chemicals or hazards that may remain.
5.3.4 Once the area is deemed safe, remove all warning signs and barriers. Notify all relevant personnel that the area is clear for use.
Note: The standard concentrations used for fumigation with potassium permanganate and formalin (formaldehyde solution) typically involve mixing these chemicals to generate formaldehyde gas. The common practice is as follows:
- Potassium Permanganate (KMnO4): Usually, about 2.5 grams of potassium permanganate is used per cubic meter of space.
- Formalin (Formaldehyde Solution, typically 37-40% concentration): Typically, 25 ml of formalin is used per cubic meter of space.
Preparation Process:
- The formalin and potassium permanganate are mixed together in a container to initiate a chemical reaction that produces formaldehyde gas, which is used for fumigation.
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