ACECLOFENAC – Uses, Dosage, Pharmacology, Mechanism of Action, Side Effects, Contraindication & Interaction

Aceclofenac

•      
Aceclofenac is a nonsteroidal anti-inflammatory
drug (NSAID)

•      
Analog of diclofenac

•       It was patented in 1983 and approved for medical
use in 1992

USE

•         
Rheumatoid Arthritis

•         
Osteoarthritis

•         
Ankylosing Spondylitis

•         
Mild to moderate pain

•         
Inflammation

DOSE

•      
Adults – The recommended dose is 200 mg
daily, taken as two separate 100 mg doses, one tablet in the morning and one in
the evening.

•      
Paediatric population – It is not
recommended for use in children under 18 years of age.

PHARMACOLOGY

•      
Absorption – rapidly and completely
absorbed from the gastrointestinal tract

•      
Volume of distribution – 25L

•      
Protein binding – Highly protein-bound
(>99%)

•      
Route of elimination – urine (70-80%),
feces (20%)

•      
Half-life – approximately 4 hours

•      
Clearance – 5 L/h 

MACHENISM OF
ACTION

•      
Prostaglandins are substances which is
responsible for the sensation of pain, swelling, and inflammation.

•      
Aceclofenac is a nonsteroidal anti-inflammatory
drug (NSAIDs) and works by blocking the activity of an enzyme that is
responsible for the formation of prostaglandins, thus relieving pain, swelling
and inflammation.

SIDE EFFECTS

•      
Vomiting

•      
Stomach pain/epigastric pain

•      
Nausea

•      
Indigestion

•      
Diarrhea

•      
Heartburn

•      
Loss of appetite

PRECAUTIONS/CONTRAINDICATION

•      
Allergies- Avoid if you have a known
allergy to Aceclofenac or other ANSIDs.

•      
Asthma- Not recommended if you have been
diagnosed with asthma.

•      
Bleeding – Aceclofenac is not recommended
if you have any bleeding disorder. It may cause severe swelling and bleed in
the stomach, colon, and anus.

•      
Pregnancy- This medicine is not
recommended in pregnant women.

•      
Breast-nutrition- This medicine is not
recommended for breastfeeding women.

•      
Gastrointestinal bleeding- Cause severe
bleeding when taken for a long time. Elderly populations with a history of
gastrointestinal disease are at higher risk.

•      
Cardiac surgery- Not be used to relieve
pain before or after CABG (coronary artery bypass surgery).

•      
Kidney- Not recommended if you have
impaired kidney function.

•      
Liver- Use with caution with an initial
dose of 100 mg once daily for mild liver failure. Contraindicated in the severe
failure of the liver.

Interaction
with Medicine

•      
Corticosteroids – Moderate

•      
Antihypertensives – Severe

•      
Digoxin– Severe

•      
Warfarin– Severe

•      
Lithium– Severe

FAMOUS
BRANDS