Haematinics
Contents
• Haematinics
• The monograph analysis of:
Ferrous Sulphate
Ferrous gluconate
Learning Objectives
At the end of this lecture, the student will be able to:
• Define Haematinics
• Explain the monograph analysis of:
Ferrous Sulphate
Ferrous gluconate
Definition
Haematinics: Used for treating anaemia or To increase the haemoglobin content
Haematinics
Haematinics, often referred to as hematopoietic agents, are essential components for maintaining healthy blood production. These vital nutrients play a crucial role in preventing and treating various types of anemia, a condition characterized by a low count of red blood cells or a lack of hemoglobin in the blood. I
Monograph of Ferrous sulphate
Name: Ferrous sulphate
Chemical formula: FeSO4,7H2O
Molecular weight: 278.0
Standard: Ferrous Sulphate contains not less than 98.0 per cent and not more than 105.0 percent of H2O
Synonym: Green vitriol
Method of preparation:
Fe2+ + H2SO4 à FeSO4 + H2
Properties of ferrous sulphate:
Description: Bluish green crystals or a light green, crystalline powder; odourless. Efflorescent in air. On exposure to moist air, the crystals rapidly oxidise and become brown
Test for purity:
Appearance of solution
Manganese
pH
Chlorides
Arsenic
Copper
Lead
Zinc
Assay: principle
Ce4+ + e ⎯⎯→ Ce3+ (Reduction-half reaction)
Ceric Cerrous
Fe2+ − e ⎯⎯→ Fe3+ (Oxidation-half reaction)
Ferrous Ferric
Ce4+ + Fe2+ ⎯→ Ce3+ + Fe3+ (oxidation-reduction reaction)
Indicator: Ferrion Sulphate
Colour change: red to blue
Medicinal uses: Haematinics
Storage: store protected from light and moisture.
Monograph of Ferrous gluconate
Name: Ferrous gluconate
Chemical formula: C12H22FeO14,xH2O
Molecular weight: 446.1
Standard: Ferrous Gluconate contains not less than 95.0 per cent and not more than 102.0 per cent of C12H22FeO14, calculated on the dried basis.
Method of preparation
Properties of ferrous gluconate:
Description: A yellowish grey or pale greenish-yellow, fine powder or granules; odour, slight, resembling that of burnt sugar.
Test for purity:
Ferric iron
Arsenic
Heavy metals
Oxalic acid
Reducing sugars
Loss on drying
Chlorides
Sulphates
Barium
Assay: principle
Ce4+ + e ⎯⎯→ Ce3+ (Reduction-half reaction)
Ceric Cerrous
Fe2+ − e ⎯⎯→ Fe3+ (Oxidation-half reaction)
Ferrous Ferric
Ce4+ + Fe2+ ⎯→ Ce3+ + Fe3+ (oxidation-reduction reaction)
Indicator: Ferrion sulphate
Colour change: red to blue
Medicinal uses:
• Haematinics
Storage: store protected from light and moisture
Summary
• Haematinics: treatment of anaemia
• Ferrous Sulphate: Widely used compound in various dosage form
• Ferrous gluconate: Less side effects compared to other salts
• Iron compounds are estimated by cerrimetry or permanganometry
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