Haematinics – Pharmaceutical Inorganic Chemistry B. Pharma 1st Semester

Haematinics

Contents

• Haematinics

• The monograph analysis of:

 Ferrous Sulphate

 Ferrous gluconate

Learning
Objectives

At the end of this
lecture, the student will be able to:

• Define Haematinics

• Explain the monograph analysis of:

 Ferrous Sulphate

 Ferrous gluconate

Definition

Haematinics: Used
for treating anaemia or To increase the haemoglobin content

Monograph
of Ferrous sulphate

Name: Ferrous
sulphate

Chemical formula:
FeSO4,7H2O

Molecular weight:
278.0

Standard: Ferrous
Sulphate contains not less than 98.0 per cent and not more than 105.0 percent
of H2O

Synonym: Green
vitriol

Method of
preparation:

Fe2+ + H2SO4 à
FeSO4 + H2

Properties of ferrous
sulphate:

Description:
Bluish green crystals or a light green, crystalline powder; odourless.
Efflorescent in air. On exposure to moist air, the crystals rapidly oxidise and
become brown

Test for purity:

Appearance of solution

Manganese

pH

Chlorides

Arsenic

Copper

Lead

Zinc

Assay: principle

Ce4+ + e ⎯⎯ Ce3+  (Reduction-half reaction)

Ceric          
Cerrous

Fe2+ − e ⎯⎯ Fe3+
(Oxidation-half reaction)

Ferrous         Ferric

Ce4+ + Fe2+ Ce3+ + Fe3+ (oxidation-reduction
reaction)

Indicator:
Ferrion Sulphate

Colour change:
red to blue

Medicinal uses:

Haematinics

Storage: store
protected from light and moisture.

Monograph
of Ferrous gluconate

Name: Ferrous
gluconate

Chemical formula:
C12H22FeO14,xH2O

Molecular weight:
446.1

Standard: Ferrous
Gluconate contains not less than 95.0 per cent and not more than 102.0 per cent
of C12H22FeO14, calculated on the dried basis.

Method of preparation

Properties of ferrous
gluconate:

Description: A
yellowish grey or pale greenish-yellow, fine powder or granules; odour, slight,
resembling that of burnt sugar.

Test for purity:

Ferric iron

Arsenic

Heavy metals

Oxalic acid

Reducing sugars

Loss on drying

Chlorides

Sulphates

Barium

Assay: principle

Ce4+ + e ⎯⎯ Ce3+
(Reduction-half reaction)

Ceric          Cerrous

Fe2+ − e ⎯⎯ Fe3+
(Oxidation-half reaction)

Ferrous          Ferric

Ce4+ + Fe2+ Ce3+ + Fe3+ (oxidation-reduction
reaction)

Indicator:
Ferrion sulphate

Colour change:
red to blue

Medicinal uses:

• Haematinics

Storage: store
protected from light and moisture

Summary

• Haematinics: treatment of anaemia

• Ferrous Sulphate: Widely used compound in various dosage
form

• Ferrous gluconate: Less side effects compared to other
salts

• Iron compounds are estimated by cerrimetry or
permanganometry

 

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