Haematinics
Contents
• Haematinics
• The monograph analysis of:
Ferrous Sulphate
Ferrous gluconate
Learning
Objectives
At the end of this
lecture, the student will be able to:
• Define Haematinics
• Explain the monograph analysis of:
Ferrous Sulphate
Ferrous gluconate
Definition
Haematinics: Used
for treating anaemia or To increase the haemoglobin content
Monograph
of Ferrous sulphate
Name: Ferrous
sulphate
Chemical formula:
FeSO4,7H2O
Molecular weight:
278.0
Standard: Ferrous
Sulphate contains not less than 98.0 per cent and not more than 105.0 percent
of H2O
Synonym: Green
vitriol
Method of
preparation:
Fe2+ + H2SO4 à
FeSO4 + H2
Properties of ferrous
sulphate:
Description:
Bluish green crystals or a light green, crystalline powder; odourless.
Efflorescent in air. On exposure to moist air, the crystals rapidly oxidise and
become brown
Test for purity:
Appearance of solution
Manganese
pH
Chlorides
Arsenic
Copper
Lead
Zinc
Assay: principle
Ce4+ + e ⎯⎯→ Ce3+ (Reduction-half reaction)
Ceric
Cerrous
Fe2+ − e ⎯⎯→ Fe3+
(Oxidation-half reaction)
Ferrous Ferric
Ce4+ + Fe2+ ⎯→ Ce3+ + Fe3+ (oxidation-reduction
reaction)
Indicator:
Ferrion Sulphate
Colour change:
red to blue
Medicinal uses:
Haematinics
Storage: store
protected from light and moisture.
Monograph
of Ferrous gluconate
Name: Ferrous
gluconate
Chemical formula:
C12H22FeO14,xH2O
Molecular weight:
446.1
Standard: Ferrous
Gluconate contains not less than 95.0 per cent and not more than 102.0 per cent
of C12H22FeO14, calculated on the dried basis.
Method of preparation
Properties of ferrous
gluconate:
Description: A
yellowish grey or pale greenish-yellow, fine powder or granules; odour, slight,
resembling that of burnt sugar.
Test for purity:
Ferric iron
Arsenic
Heavy metals
Oxalic acid
Reducing sugars
Loss on drying
Chlorides
Sulphates
Barium
Assay: principle
Ce4+ + e ⎯⎯→ Ce3+
(Reduction-half reaction)
Ceric Cerrous
Fe2+ − e ⎯⎯→ Fe3+
(Oxidation-half reaction)
Ferrous Ferric
Ce4+ + Fe2+ ⎯→ Ce3+ + Fe3+ (oxidation-reduction
reaction)
Indicator:
Ferrion sulphate
Colour change:
red to blue
Medicinal uses:
• Haematinics
Storage: store
protected from light and moisture
Summary
• Haematinics: treatment of anaemia
• Ferrous Sulphate: Widely used compound in various dosage
form
• Ferrous gluconate: Less side effects compared to other
salts
• Iron compounds are estimated by cerrimetry or
permanganometry