Tranquilizers

• A tranquilizer is a drug which
is designed for the treatment of anxiety, fear, tension, agitation, and
disturbances of the mind, specifically to reduce states of anxiety and tension.

• Psychoses mean mental condition raised
by disturbance in mental function.

• Mental disease has always been
puzzling and frightening things.

• They are quite different from other
disease of mankind.

Psychoses
may be:

1. Organic psychoses where there is
memory distrurnace clouding of consciousness due to endocrinal abnormalities of
head injury.

2. Functional psychoses may be:

a) Manic: disturbance of mood.

b) Schizophrenia in which there is
disordered of thoughts emotions

c) Hallucinations

d) Anxiety where feeling of fear.

Classifications of Tranquilizers:

1. Phenothiazine
derivatives and related tricyclic compound:

a) Phenothiazine
derivatives: e.g. chlorpromazine, Prochlorperazine trifluoroperazine.

b) Thioxanthenes
derivatives: e.g. chlorprothixene ,flupenthixol

2. Butyrophenones: e.g. haloperidol,
trifluoperidol (Triperidol)

3. Dibenzodiazepines: e.g. clozapine

4. Benzamides and salicylamides e.g.
Sulpiride

5. Diphenyl butyl piperidine
derivatives: e.g. pimozide

6. Miscellaneous: e.g. Reserpine.

Chlorpromazine

Structure of Chlorpromazine: