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Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

This quiz offers 60 meticulously selected questions from previous pharmacist exams, focusing on crucial topics in pharmacology and toxicology Quiz. Designed to help candidates excel in competitive exams such as GPAT, NIPER, Drug Inspector, Pharmacist, and RRB Pharmacist, this quiz provides valuable practice for mastering key concepts. Enhance your preparation and boost your confidence with real exam-based questions that target the areas frequently tested in various pharma competitive exams. Whether you’re revising or testing your knowledge, this quiz is a vital tool for success!

Pharmacology and Toxicology Quiz 1

Pharmacology and Toxicology Quiz Based of Previous Year Pharmacist Exam Paper Part 1

Get ready to test your knowledge in the field of Pharmacology and Toxicology. Please click on the right option to answer the questions. Good luck!

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1 / 60

1. Which of the following is the WHO Collaborating Centre for Pharmacovigilance in Public Health Programmes and Regulatory Services?

MPSC Pharmacist (08.02.2023)

a. Indian Pharmacopoeia Commission

b. Norwegian Institute of Public Health

c. The Netherlands Pharmacovigilance Centre Lareb

d. Uppsala Monitoring Centre

2 / 60

2. Nitric oxide synthase exists in __________

GPAT(09.04.2022)

a. Two isoforms

b. Four isoforms

c. Three isoforms

d. Five isoforms

3 / 60

3. Which of the following antihistaminic drug is a propylamine derivative?

UPSSSC Pharmacist (26.03.2023)

a. Pyrilamine

b. Chlorpheniramine

c. Cyclizine

d. Diphenhydramine

4 / 60

4. Which of the following is not an endogenous compound?

Lucknow Cantonment Board Pharmacist (05.02.2023)

a. Noradrenaline

b. Endorphins

c. Desipramine

d. Dopamine

5 / 60

5. Which of the following statements related to the location of drug information services/centre is INCORRECT?

MPSC Pharmacist (08.02.2023)

a. It should be near the operation theatre.

b. It should be away from inpatient and outpatient departments.

c. It should be near the hospital library.

d. It should be near the pharmacy department.

6 / 60

6. The TDM refers to:

MPSC Pharmacist (08.02.2023)

a. Therapeutic Drug Monitoring

b. Treatment Drug Monitoring

c. Therapeutic Dose Management

d. Therapeutic Dose Monitoring

7 / 60

7. Chlorpromazine exerts antipsychotic action by_____

HPSSC Pharmacist(22.08.2022)

a. Depleting stores of catecholamines

b. Depleting stores of 5-Hydroxy tryptamine in brain

c. Inhibition of hypothalamic stimulation responses

d. Blocking postsynaptic dopamine receptors

8 / 60

8. A suppository is generally intended for use in________

UPSSSC Pharmacist (26.03.2023)

a. Urethra

b. All of these

c. Vagina

d. Rectum

9 / 60

9. Which of the following agents is NOT a teratogen?

MPSC Pharmacist (08.02.2023)

a. Amphotericin B

b. Streptomycin

c. Thalidomide

d. Tetracyciline

10 / 60

10. Which of the following effect is produced by Saroglitazar?

MPSC Pharmacist (08.02.2023)

a. Lowering the LDL-CH in plasma

b. Increasing the HDL is plasma

c. Lowering the LDL in plasma

d. Decrease the glucose as well as lipid in plasma

11 / 60

11. Which of the following dye is used for the leakage test?

Lucknow Cantonment Board Pharmacist (05.02.2023)

a. Methylene blue

b. Methylene rose

c. Methyl violet

d. Methyl orange

12 / 60

12. Match List I with List II Match the following with their mechanism of action:

GPAT(09.04.2022)

a. A ‐ II, B ‐ III, C ‐IV , D ‐I

b. A ‐II , B ‐V , C ‐III , D ‐IV

c. A ‐IV, B ‐ I, C ‐V , D ‐III

d. A ‐IV , B ‐III , C ‐II , D ‐I

13 / 60

13. Choose the correct example of proton pump inhibitor.

UPSSSC Pharmacist (26.03.2023)

a. Alprazolam

b. Albendazole

c. Itraconazole

d. Pantoprazole

14 / 60

14. Ivermectin exerts its anthelmintic action through:

MPSC Pharmacist (08.02.2023)

a. Leakage of intracellular Ca +2

b. Activation of glycine gated c1- channel

c. Activation of glutamate gated ci- channel

d. Activation of nicotinic cholinergic receptors

15 / 60

15. Which of the following is not an action of amphetamine?

HPSSC Pharmacist(22.08.2022)

a. Increased mental and physical activity

b. Reduces appetite

c. Potent CNS stimulation

d. Decreasing systolic and diastolic BP

16 / 60

16. Antihypertensive drugs are an example of:

UP NHM Pharmacist (29.12.2022)

a. standard dose

b. titrated dose

c. regulated dose

d. target level dose

17 / 60

17. A neonate suffering from icterus is intravenously administered with phenobarbital. The justification for this therapy is:

GPAT(09.04.2022)

a. Phenobarbital suppresses the bilirubin synthesis in neonatesj

b. Phenoarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin

c. Phenobarbital suppresses hepatic glucuronyl transferase and increases clearance of bilirubin

d. Phenobarbital is a short acting barbiturate and hence safe to induce sleep in neonates

18 / 60

18. The following drug is acting by inhibition HMG-Co-A enzyme:

UPSSSC Pharmacist (26.03.2023)

a. Rosuvastatin

b. Penicillin

c. Fenofibrate

d. Streptokinas

19 / 60

19. Adverse side effects of Selective Serotonin Reuptake Inhibitors like insomnia, increased anxiety, irritability and decrease libido are due to:

MPSC Pharmacist (08.02.2023)

a. Excessive stimulation of brain 5HT3 receptors

b. (a) Excessive stimulation of brain 5HT1B receptors

c. Excessive stimulation of brain 5HT4 receptors

d. Excessive stimulation of brain 5HT2 receptors

20 / 60

20. The ‘Up‐and‐Down’ method for a projected LD50 determination is described in the…..

GPAT(09.04.2022)

a. OECD Guideline 423

b. OECD Guideline 420

c. OECD Guideline 401

d. OECD Guideline 425

21 / 60

21. __________ are drugs which treat rhinitis and other allergic conditions.

UP NHM Pharmacist (29.12.2022)

a. Antihistamines

b. Amphetamine

c. Penicillamine

d. Antimicrobial agents

22 / 60

22. Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme

Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. A, B and D only are correct

b. All A, B, C and D are correct

c. Only B is correct

d. Only A and B are correct

23 / 60

23. Which of the following is a correct match of drug and its mechanism of action in the management of congestive heart failure?

MPSC Pharmacist (08.02.2023)

a. Dobutamine - Reduced heart rate

b. Torasemide - Afterload reduction

c. Hydralazine - Preload reduction

d. Levosimendan - Positive inotropic effect

24 / 60

24. An example of pyrazolone derivative analgesic is______

HPSSC Pharmacist(22.08.2022)

a. Phenacetin

b. Mefanamic acid

c. Indomethacine

d. Phenylbutazone

25 / 60

25. Which of the following is a sod-glucose cotransport-2 (SGLT-2) inhibitor?

MPSC Pharmacist (08.02.2023)

a. Voglibose

b. Dapagliflozin

c. Pioglitazone

d. Sitagliptin

26 / 60

26. Bleeding due to displacement of warfarin from protein-binding sites is a type of ________ drug interaction.

UP NHM Pharmacist (29.12.2022)

a. analgesic

b. anticoagulant

c. antihypertensive

d. oral antidiabetic

27 / 60

27. __________ are the agents that help in lowering increased lipid levels.

UP NHM Pharmacist (29.12.2022)

a. Antihypertensive drugs

b. Antidotes

c. Hypolipidemic drugs

d. Haematinics

28 / 60

28. General anaesthetics are_____ of the central nervous system.

UP NHM Pharmacist (29.12.2022)

a. Stabilisers

b. Activators

c. Depressants

d. Stimulators

29 / 60

29. Phenformin was withdrawn worldwide owing to high risk of:

MPSC Pharmacist (08.02.2023)

a. Keto acidosis

b. Keto alkalosis

c. Lactic acidosis

d. Lactic alkalosis

30 / 60

30. Which of the following statements is NOT true regarding Gemfibrozil?

MPSC Pharmacist (08.02.2023)

a. It markedly reduces circulating VLDL and triglyceride.

b. With statins, it increases the chances of myopathy.

c. It decreases the synthesis of lipoprotein lipase.

d. It is an agonist at PPAR-α nuclear receptors.

31 / 60

31. _____ is an example of high sedative.

UP NHM Pharmacist (29.12.2022)

a. Pheniramine

b. Diphenhydramine

c. Cyproheptadine

d. Chlorpheniramine

32 / 60

32. Which antihypertensive drug is a direct renin inhibitor?

MPSC Pharmacist (08.02.2023)

a. Moxonidine

b. Phenoxybenzamine

c. Moexipril

d. Aliskiren

33 / 60

33. How many pharmacists are required for a 100-bed hospital?

UP NHM Pharmacist (29.12.2022)

a. 02

b. 06

c. 10

d. 05

34 / 60

34. The following drug is dopaminergic agonist:

UPSSSC Pharmacist (26.03.2023)

a. Carbidopa

b. Selegiline

c. Bromocriptine

d. Entacapone

35 / 60

35. The quadruple therapy of Helicobacter pylori infection includes:

GPAT(09.04.2022)

a. Sulfasalazine, metronidazole, tetracycline and a proton pump inhibitor

b. Streptomycin, metronidazole, tetracycline and a proton pump inhibitor

c. Bismuth subsalicylate, metronidazole, azithromycin and a proton pump inhibitor

d. Bismuth subsalicylate, metronidazole, tetracycline and a proton pump inhibitor

36 / 60

36. Which of the following is not a screening method for antidiabetic agents?

UP NHM Pharmacist (29.12.2022)

a. Bio-breeding rat

b. Euglcaemic clamp technique

c. Adrenaline-induced acute hyperglcaemia

d. Tooth pulp stimulation

37 / 60

37. Which of the following is not a muscarinic action of Acetylcholine?

HPSSC Pharmacist(22.08.2022)

a. Vasodilation

b. Decrease in heart rate

c. Increase in tone and activity of smooth muscle

d. Inhibition of gastric secretions

38 / 60

38. Which of the following antidiabetic drug is Sulfonyl urea derivative?

UPSSSC Pharmacist (26.03.2023)

a. Glibenclamide

b. Metformin

c. Linagliptin

d. Pioglitazone

39 / 60

39. ____________ is the study of how the body interacts with administered substances for the entire duration of exposure.

UP NHM Pharmacist (29.12.2022)

a. Pharmacokinetics

b. Bioactivation

c. Pharmacodynamics

d. Biotransformation

40 / 60

40. Pyrazinamide is______

HPSSC Pharmacist(22.08.2022)

a. Pyrazine-2-carboxamide

b. Pyrazine-4-carboxamide

c. Pyrazine-1-carboxamide

d. Pyrazine-3-carboxamide

41 / 60

41. Reduced bronchodilation by a beta2 agonist prescribed with a non-selective beta-blocker is an example of:

MPSC Pharmacist (08.02.2023)

a. Pharmacodynamic drug-drug interaction

b. Pharmacokinetic drug-drug interaction

c. Behavioural drug-drug interaction

d. Pharmaceutical drug-drug interaction

42 / 60

42. Scientific research is the primary source of:

UP NHM Pharmacist (29.12.2022)

a. Review articles

b. Drug information

c. Database

d. Textbooks

43 / 60

43. A patient with pheochromcytoma is undergoing surgery and has not been administered with alpha receptor blocker. If he is administered with intravenous propranolol, then which of the following effects will be evident?

GPAT(09.04.2022)

a. The blood pressure will remain unchanged

b. There will be a rise in the blood pressure

c. The patient may suffer severe bronchoconstriction

d. There will be a fall in the blood pressure

44 / 60

44. Which drug is an HIV protease inhibitor?

MPSC Pharmacist (08.02.2023)

a. Nevirapine

b. Acyclovir

c. Lopinavir

d. Delavirdine

45 / 60

45. Sympathetic blocking drug “guanethidine” acts by

HPSSC Pharmacist(22.08.2022)

a. By interfering with synthesis of adrenergic transmitter

b. By blocking adrenergic receptors

c. Interfering with transmission of impulse across postganglionic adrenergic neuron

d. Depleting catecholamines

46 / 60

46. Pilocarpine is______

HPSSC Pharmacist(22.08.2022)

a. Selective muscarinic receptor agonist

b. Non selective muscarinic receptor antagonist

c. Non selective muscarinic receptor agonist

d. Selective muscarinic receptor antagonist

47 / 60

47. Dapagliflozin causes hypoglycaemia by:

MPSC Pharmacist (08.02.2023)

a. Increased glucose uptake in cell

b. Inhibiting gluconeogenesis in liver an kidney

c. sensitizing insulin receptors

d. Increasing glucose excretion in urine

48 / 60

48. Which of the following drugs acts as ulcer protective agent?

MPSC Pharmacist (08.02.2023)

a. Sucralfate

b. Ambroxol

c. Cimetidine

d. Sodium citrate

49 / 60

49. Which of the following drug is used in Herpes infection?

UPSSSC Pharmacist (26.03.2023)

a. Idoxuridine

b. Efavirenz

c. Zidovudine

d. Amantadine

50 / 60

50. Tendon rupture or tendonitis of Achilles tendon is an adverse reaction of:

GPAT(09.04.2022)

a. Aminoglycosides

b. Fluoroquinolones

c. Tetracyclines

d. Cephalosporins

51 / 60

51. Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to_____

GPAT(09.04.2022)

a. Suppress gastroenteritis‐related vomiting

b. Inhibits the side effects of Diphenoxylate

c. Discourage abuse of Diphenoxylate

d. Augment the anti‐motility action of Diphenoxylate

52 / 60

52. Match List I with List II, Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. 1:T, 2:Q, 3: R, 4:P, 5:S

b. 1:P, 2:Q, 3: T, 4: S, 5: R

c. 1:Q, 2:S, 3:P, 4:R, 5: T

d. 1:R, 2:Q, 3: S, 4: T, 5: P

53 / 60

53. Bitter metallic taste is characteristic of drug

HPSSC Pharmacist(22.08.2022)

a. Glibenclamide

b. Mepyramine

c. Tetracycline

d. Phenformin

54 / 60

54. How does phenylephrine differs from adrenaline?

UPSSSC Pharmacist (26.03.2023)

a. Lacking 4-COOH group on the benzene ring.

b. Lacking 4-CONH2 group on the benzene ring

c. Lacking 4-NH group on the benzene ring.

d. Lacking 4-OH group on the benzene ring.

55 / 60

55. Which enzyme catalyses the bioactivation of nitroglycerin into NO?

MPSC Pharmacist (08.02.2023)

a. Glycerol kinase

b. Tyrosine kinase

c. Glycerol dehydrogenase

d. Aldehyde dehydrogenase 2

56 / 60

56. Regarding Bromocriptine, which of the following statement is TRUE It is a relatively selective dopamine D2 agonist with prominent action
A. on pituitary lactotrophs (inhibit prolactin release)
B. in striatum (antiparkinsonian)
C. in CTZ (antiemetic)
D. as an adjunctive treatment for type 2 DM
Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. A, B and D only

b. B and D only

c. A and B only

d. A, B and C only

57 / 60

57. Clofazimine is a/an _____derivative. Or Which of the following heterocyclic ring is present in Clofazimine which is used for the treatment of leprosy?

AMC Pharmacist (05.11.2023), HPSSC Pharmacist(12.12.2020)

a. Phenothiazine

b. Phenazine

c. Azepine

d. Pyrazi

58 / 60

58. Penicillin produces _____ upon hydrolysis with hot dilute inorganic acids.

HPSSC Pharmacist(22.08.2022)

a. Propicillin

b. Penicillamine

c. Benzyl penicillin

d. Pencilloic acid

59 / 60

59. An example of adsorbent is________

HPSSC Pharmacist(22.08.2022)

a. Magnesium stearate

b. Cellulose

c. Magnesium silicate

d. Acacia

60 / 60

60. In ADR, unusual and unexpected drug effects are known as:

MPSC Pharmacist (08.02.2023)

a. Secondary pharmacological effects

b. Idiosyncrasy

c. Allergic drug reactions

d. Excessive pharmacological effects

Your score is

The average score is 37%

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Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

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