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Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

This quiz offers 60 meticulously selected questions from previous pharmacist exams, focusing on crucial topics in pharmacology and toxicology Quiz. Designed to help candidates excel in competitive exams such as GPAT, NIPER, Drug Inspector, Pharmacist, and RRB Pharmacist, this quiz provides valuable practice for mastering key concepts. Enhance your preparation and boost your confidence with real exam-based questions that target the areas frequently tested in various pharma competitive exams. Whether you’re revising or testing your knowledge, this quiz is a vital tool for success!

Pharmacology and Toxicology Quiz 1

Pharmacology and Toxicology Quiz Based of Previous Year Pharmacist Exam Paper Part 1

Get ready to test your knowledge in the field of Pharmacology and Toxicology. Please click on the right option to answer the questions. Good luck!

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1 / 60

1. A patient with pheochromcytoma is undergoing surgery and has not been administered with alpha receptor blocker. If he is administered with intravenous propranolol, then which of the following effects will be evident?

GPAT(09.04.2022)

a. The patient may suffer severe bronchoconstriction

b. The blood pressure will remain unchanged

c. There will be a fall in the blood pressure

d. There will be a rise in the blood pressure

2 / 60

2. Pilocarpine is______

HPSSC Pharmacist(22.08.2022)

a. Selective muscarinic receptor agonist

b. Non selective muscarinic receptor antagonist

c. Non selective muscarinic receptor agonist

d. Selective muscarinic receptor antagonist

3 / 60

3. Dapagliflozin causes hypoglycaemia by:

MPSC Pharmacist (08.02.2023)

a. Increased glucose uptake in cell

b. Inhibiting gluconeogenesis in liver an kidney

c. sensitizing insulin receptors

d. Increasing glucose excretion in urine

4 / 60

4. The following drug is acting by inhibition HMG-Co-A enzyme:

UPSSSC Pharmacist (26.03.2023)

a. Penicillin

b. Rosuvastatin

c. Fenofibrate

d. Streptokinas

5 / 60

5. Which of the following is not an action of amphetamine?

HPSSC Pharmacist(22.08.2022)

a. Potent CNS stimulation

b. Decreasing systolic and diastolic BP

c. Increased mental and physical activity

d. Reduces appetite

6 / 60

6. Pyrazinamide is______

HPSSC Pharmacist(22.08.2022)

a. Pyrazine-1-carboxamide

b. Pyrazine-3-carboxamide

c. Pyrazine-4-carboxamide

d. Pyrazine-2-carboxamide

7 / 60

7. __________ are the agents that help in lowering increased lipid levels.

UP NHM Pharmacist (29.12.2022)

a. Hypolipidemic drugs

b. Antidotes

c. Antihypertensive drugs

d. Haematinics

8 / 60

8. Scientific research is the primary source of:

UP NHM Pharmacist (29.12.2022)

a. Review articles

b. Textbooks

c. Drug information

d. Database

9 / 60

9. Regarding Bromocriptine, which of the following statement is TRUE It is a relatively selective dopamine D2 agonist with prominent action
A. on pituitary lactotrophs (inhibit prolactin release)
B. in striatum (antiparkinsonian)
C. in CTZ (antiemetic)
D. as an adjunctive treatment for type 2 DM
Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. A, B and D only

b. A and B only

c. B and D only

d. A, B and C only

10 / 60

10. A neonate suffering from icterus is intravenously administered with phenobarbital. The justification for this therapy is:

GPAT(09.04.2022)

a. Phenobarbital suppresses the bilirubin synthesis in neonatesj

b. Phenobarbital suppresses hepatic glucuronyl transferase and increases clearance of bilirubin

c. Phenobarbital is a short acting barbiturate and hence safe to induce sleep in neonates

d. Phenoarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin

11 / 60

11. Which drug is an HIV protease inhibitor?

MPSC Pharmacist (08.02.2023)

a. Lopinavir

b. Delavirdine

c. Acyclovir

d. Nevirapine

12 / 60

12. Antihypertensive drugs are an example of:

UP NHM Pharmacist (29.12.2022)

a. target level dose

b. standard dose

c. titrated dose

d. regulated dose

13 / 60

13. Which of the following is the WHO Collaborating Centre for Pharmacovigilance in Public Health Programmes and Regulatory Services?

MPSC Pharmacist (08.02.2023)

a. Norwegian Institute of Public Health

b. The Netherlands Pharmacovigilance Centre Lareb

c. Indian Pharmacopoeia Commission

d. Uppsala Monitoring Centre

14 / 60

14. The TDM refers to:

MPSC Pharmacist (08.02.2023)

a. Therapeutic Dose Monitoring

b. Therapeutic Dose Management

c. Treatment Drug Monitoring

d. Therapeutic Drug Monitoring

15 / 60

15. Which enzyme catalyses the bioactivation of nitroglycerin into NO?

MPSC Pharmacist (08.02.2023)

a. Glycerol kinase

b. Aldehyde dehydrogenase 2

c. Glycerol dehydrogenase

d. Tyrosine kinase

16 / 60

16. In ADR, unusual and unexpected drug effects are known as:

MPSC Pharmacist (08.02.2023)

a. Excessive pharmacological effects

b. Secondary pharmacological effects

c. Allergic drug reactions

d. Idiosyncrasy

17 / 60

17. Bleeding due to displacement of warfarin from protein-binding sites is a type of ________ drug interaction.

UP NHM Pharmacist (29.12.2022)

a. oral antidiabetic

b. antihypertensive

c. analgesic

d. anticoagulant

18 / 60

18. Sympathetic blocking drug “guanethidine” acts by

HPSSC Pharmacist(22.08.2022)

a. By blocking adrenergic receptors

b. Interfering with transmission of impulse across postganglionic adrenergic neuron

c. By interfering with synthesis of adrenergic transmitter

d. Depleting catecholamines

19 / 60

19. Ivermectin exerts its anthelmintic action through:

MPSC Pharmacist (08.02.2023)

a. Activation of glutamate gated ci- channel

b. Leakage of intracellular Ca +2

c. Activation of glycine gated c1- channel

d. Activation of nicotinic cholinergic receptors

20 / 60

20. Which of the following antihistaminic drug is a propylamine derivative?

UPSSSC Pharmacist (26.03.2023)

a. Pyrilamine

b. Diphenhydramine

c. Cyclizine

d. Chlorpheniramine

21 / 60

21. Which of the following agents is NOT a teratogen?

MPSC Pharmacist (08.02.2023)

a. Tetracyciline

b. Streptomycin

c. Thalidomide

d. Amphotericin B

22 / 60

22. Adverse side effects of Selective Serotonin Reuptake Inhibitors like insomnia, increased anxiety, irritability and decrease libido are due to:

MPSC Pharmacist (08.02.2023)

a. Excessive stimulation of brain 5HT3 receptors

b. (a) Excessive stimulation of brain 5HT1B receptors

c. Excessive stimulation of brain 5HT4 receptors

d. Excessive stimulation of brain 5HT2 receptors

23 / 60

23. Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme

Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. Only B is correct

b. Only A and B are correct

c. All A, B, C and D are correct

d. A, B and D only are correct

24 / 60

24. The ‘Up‐and‐Down’ method for a projected LD50 determination is described in the…..

GPAT(09.04.2022)

a. OECD Guideline 401

b. OECD Guideline 423

c. OECD Guideline 425

d. OECD Guideline 420

25 / 60

25. Which antihypertensive drug is a direct renin inhibitor?

MPSC Pharmacist (08.02.2023)

a. Moxonidine

b. Phenoxybenzamine

c. Aliskiren

d. Moexipril

26 / 60

26. ____________ is the study of how the body interacts with administered substances for the entire duration of exposure.

UP NHM Pharmacist (29.12.2022)

a. Biotransformation

b. Bioactivation

c. Pharmacokinetics

d. Pharmacodynamics

27 / 60

27. Match List I with List II Match the following with their mechanism of action:

GPAT(09.04.2022)

a. A ‐IV , B ‐III , C ‐II , D ‐I

b. A ‐II , B ‐V , C ‐III , D ‐IV

c. A ‐IV, B ‐ I, C ‐V , D ‐III

d. A ‐ II, B ‐ III, C ‐IV , D ‐I

28 / 60

28. Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to_____

GPAT(09.04.2022)

a. Inhibits the side effects of Diphenoxylate

b. Augment the anti‐motility action of Diphenoxylate

c. Suppress gastroenteritis‐related vomiting

d. Discourage abuse of Diphenoxylate

29 / 60

29. Which of the following statements is NOT true regarding Gemfibrozil?

MPSC Pharmacist (08.02.2023)

a. It decreases the synthesis of lipoprotein lipase.

b. It is an agonist at PPAR-α nuclear receptors.

c. It markedly reduces circulating VLDL and triglyceride.

d. With statins, it increases the chances of myopathy.

30 / 60

30. General anaesthetics are_____ of the central nervous system.

UP NHM Pharmacist (29.12.2022)

a. Stabilisers

b. Activators

c. Stimulators

d. Depressants

31 / 60

31. Match List I with List II, Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. 1:R, 2:Q, 3: S, 4: T, 5: P

b. 1:T, 2:Q, 3: R, 4:P, 5:S

c. 1:Q, 2:S, 3:P, 4:R, 5: T

d. 1:P, 2:Q, 3: T, 4: S, 5: R

32 / 60

32. How many pharmacists are required for a 100-bed hospital?

UP NHM Pharmacist (29.12.2022)

a. 06

b. 02

c. 05

d. 10

33 / 60

33. A suppository is generally intended for use in________

UPSSSC Pharmacist (26.03.2023)

a. Vagina

b. Rectum

c. All of these

d. Urethra

34 / 60

34. Which of the following statements related to the location of drug information services/centre is INCORRECT?

MPSC Pharmacist (08.02.2023)

a. It should be near the hospital library.

b. It should be near the pharmacy department.

c. It should be away from inpatient and outpatient departments.

d. It should be near the operation theatre.

35 / 60

35. Chlorpromazine exerts antipsychotic action by_____

HPSSC Pharmacist(22.08.2022)

a. Depleting stores of 5-Hydroxy tryptamine in brain

b. Blocking postsynaptic dopamine receptors

c. Depleting stores of catecholamines

d. Inhibition of hypothalamic stimulation responses

36 / 60

36. Which of the following is not an endogenous compound?

Lucknow Cantonment Board Pharmacist (05.02.2023)

a. Dopamine

b. Endorphins

c. Noradrenaline

d. Desipramine

37 / 60

37. Which of the following drug is used in Herpes infection?

UPSSSC Pharmacist (26.03.2023)

a. Efavirenz

b. Zidovudine

c. Amantadine

d. Idoxuridine

38 / 60

38. __________ are drugs which treat rhinitis and other allergic conditions.

UP NHM Pharmacist (29.12.2022)

a. Antihistamines

b. Amphetamine

c. Penicillamine

d. Antimicrobial agents

39 / 60

39. Penicillin produces _____ upon hydrolysis with hot dilute inorganic acids.

HPSSC Pharmacist(22.08.2022)

a. Pencilloic acid

b. Benzyl penicillin

c. Propicillin

d. Penicillamine

40 / 60

40. Nitric oxide synthase exists in __________

GPAT(09.04.2022)

a. Four isoforms

b. Three isoforms

c. Two isoforms

d. Five isoforms

41 / 60

41. Bitter metallic taste is characteristic of drug

HPSSC Pharmacist(22.08.2022)

a. Mepyramine

b. Tetracycline

c. Glibenclamide

d. Phenformin

42 / 60

42. Which of the following is not a screening method for antidiabetic agents?

UP NHM Pharmacist (29.12.2022)

a. Euglcaemic clamp technique

b. Adrenaline-induced acute hyperglcaemia

c. Bio-breeding rat

d. Tooth pulp stimulation

43 / 60

43. Which of the following drugs acts as ulcer protective agent?

MPSC Pharmacist (08.02.2023)

a. Cimetidine

b. Sucralfate

c. Sodium citrate

d. Ambroxol

44 / 60

44. _____ is an example of high sedative.

UP NHM Pharmacist (29.12.2022)

a. Diphenhydramine

b. Chlorpheniramine

c. Pheniramine

d. Cyproheptadine

45 / 60

45. An example of pyrazolone derivative analgesic is______

HPSSC Pharmacist(22.08.2022)

a. Indomethacine

b. Mefanamic acid

c. Phenacetin

d. Phenylbutazone

46 / 60

46. Tendon rupture or tendonitis of Achilles tendon is an adverse reaction of:

GPAT(09.04.2022)

a. Cephalosporins

b. Fluoroquinolones

c. Tetracyclines

d. Aminoglycosides

47 / 60

47. The following drug is dopaminergic agonist:

UPSSSC Pharmacist (26.03.2023)

a. Entacapone

b. Carbidopa

c. Bromocriptine

d. Selegiline

48 / 60

48. Which of the following effect is produced by Saroglitazar?

MPSC Pharmacist (08.02.2023)

a. Increasing the HDL is plasma

b. Lowering the LDL in plasma

c. Decrease the glucose as well as lipid in plasma

d. Lowering the LDL-CH in plasma

49 / 60

49. Which of the following dye is used for the leakage test?

Lucknow Cantonment Board Pharmacist (05.02.2023)

a. Methyl orange

b. Methylene rose

c. Methyl violet

d. Methylene blue

50 / 60

50. Clofazimine is a/an _____derivative. Or Which of the following heterocyclic ring is present in Clofazimine which is used for the treatment of leprosy?

AMC Pharmacist (05.11.2023), HPSSC Pharmacist(12.12.2020)

a. Pyrazi

b. Phenothiazine

c. Phenazine

d. Azepine

51 / 60

51. Reduced bronchodilation by a beta2 agonist prescribed with a non-selective beta-blocker is an example of:

MPSC Pharmacist (08.02.2023)

a. Pharmacokinetic drug-drug interaction

b. Pharmaceutical drug-drug interaction

c. Behavioural drug-drug interaction

d. Pharmacodynamic drug-drug interaction

52 / 60

52. Which of the following is a correct match of drug and its mechanism of action in the management of congestive heart failure?

MPSC Pharmacist (08.02.2023)

a. Hydralazine - Preload reduction

b. Levosimendan - Positive inotropic effect

c. Torasemide - Afterload reduction

d. Dobutamine - Reduced heart rate

53 / 60

53. Phenformin was withdrawn worldwide owing to high risk of:

MPSC Pharmacist (08.02.2023)

a. Lactic alkalosis

b. Lactic acidosis

c. Keto acidosis

d. Keto alkalosis

54 / 60

54. Choose the correct example of proton pump inhibitor.

UPSSSC Pharmacist (26.03.2023)

a. Pantoprazole

b. Albendazole

c. Itraconazole

d. Alprazolam

55 / 60

55. The quadruple therapy of Helicobacter pylori infection includes:

GPAT(09.04.2022)

a. Bismuth subsalicylate, metronidazole, azithromycin and a proton pump inhibitor

b. Sulfasalazine, metronidazole, tetracycline and a proton pump inhibitor

c. Streptomycin, metronidazole, tetracycline and a proton pump inhibitor

d. Bismuth subsalicylate, metronidazole, tetracycline and a proton pump inhibitor

56 / 60

56. Which of the following is not a muscarinic action of Acetylcholine?

HPSSC Pharmacist(22.08.2022)

a. Inhibition of gastric secretions

b. Vasodilation

c. Decrease in heart rate

d. Increase in tone and activity of smooth muscle

57 / 60

57. Which of the following antidiabetic drug is Sulfonyl urea derivative?

UPSSSC Pharmacist (26.03.2023)

a. Metformin

b. Linagliptin

c. Pioglitazone

d. Glibenclamide

58 / 60

58. An example of adsorbent is________

HPSSC Pharmacist(22.08.2022)

a. Cellulose

b. Magnesium stearate

c. Magnesium silicate

d. Acacia

59 / 60

59. How does phenylephrine differs from adrenaline?

UPSSSC Pharmacist (26.03.2023)

a. Lacking 4-OH group on the benzene ring.

b. Lacking 4-NH group on the benzene ring.

c. Lacking 4-CONH2 group on the benzene ring

d. Lacking 4-COOH group on the benzene ring.

60 / 60

60. Which of the following is a sod-glucose cotransport-2 (SGLT-2) inhibitor?

MPSC Pharmacist (08.02.2023)

a. Voglibose

b. Pioglitazone

c. Dapagliflozin

d. Sitagliptin

Your score is

The average score is 37%

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Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

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