Post Views: 88

Table of Contents

Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

This quiz offers 60 meticulously selected questions from previous pharmacist exams, focusing on crucial topics in pharmacology and toxicology Quiz. Designed to help candidates excel in competitive exams such as GPAT, NIPER, Drug Inspector, Pharmacist, and RRB Pharmacist, this quiz provides valuable practice for mastering key concepts. Enhance your preparation and boost your confidence with real exam-based questions that target the areas frequently tested in various pharma competitive exams. Whether you’re revising or testing your knowledge, this quiz is a vital tool for success!

Pharmacology and Toxicology Quiz 1

Pharmacology and Toxicology Quiz Based of Previous Year Pharmacist Exam Paper Part 1

Get ready to test your knowledge in the field of Pharmacology and Toxicology. Please click on the right option to answer the questions. Good luck!

Please login to participate in this Quiz!

NameEmail

1 / 60

1. Which of the following is a sod-glucose cotransport-2 (SGLT-2) inhibitor?

MPSC Pharmacist (08.02.2023)

a. Dapagliflozin

b. Voglibose

c. Pioglitazone

d. Sitagliptin

2 / 60

2. Chlorpromazine exerts antipsychotic action by_____

HPSSC Pharmacist(22.08.2022)

a. Blocking postsynaptic dopamine receptors

b. Depleting stores of 5-Hydroxy tryptamine in brain

c. Depleting stores of catecholamines

d. Inhibition of hypothalamic stimulation responses

3 / 60

3. _____ is an example of high sedative.

UP NHM Pharmacist (29.12.2022)

a. Pheniramine

b. Diphenhydramine

c. Cyproheptadine

d. Chlorpheniramine

4 / 60

4. A neonate suffering from icterus is intravenously administered with phenobarbital. The justification for this therapy is:

GPAT(09.04.2022)

a. Phenoarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin

b. Phenobarbital suppresses the bilirubin synthesis in neonatesj

c. Phenobarbital suppresses hepatic glucuronyl transferase and increases clearance of bilirubin

d. Phenobarbital is a short acting barbiturate and hence safe to induce sleep in neonates

5 / 60

5. Which of the following statements is NOT true regarding Gemfibrozil?

MPSC Pharmacist (08.02.2023)

a. It is an agonist at PPAR-α nuclear receptors.

b. It markedly reduces circulating VLDL and triglyceride.

c. With statins, it increases the chances of myopathy.

d. It decreases the synthesis of lipoprotein lipase.

6 / 60

6. Which of the following antidiabetic drug is Sulfonyl urea derivative?

UPSSSC Pharmacist (26.03.2023)

a. Metformin

b. Glibenclamide

c. Pioglitazone

d. Linagliptin

7 / 60

7. Which of the following is the WHO Collaborating Centre for Pharmacovigilance in Public Health Programmes and Regulatory Services?

MPSC Pharmacist (08.02.2023)

a. Norwegian Institute of Public Health

b. Uppsala Monitoring Centre

c. Indian Pharmacopoeia Commission

d. The Netherlands Pharmacovigilance Centre Lareb

8 / 60

8. Dapagliflozin causes hypoglycaemia by:

MPSC Pharmacist (08.02.2023)

a. Increasing glucose excretion in urine

b. sensitizing insulin receptors

c. Increased glucose uptake in cell

d. Inhibiting gluconeogenesis in liver an kidney

9 / 60

9. A suppository is generally intended for use in________

UPSSSC Pharmacist (26.03.2023)

a. Vagina

b. Rectum

c. All of these

d. Urethra

10 / 60

10. Which of the following antihistaminic drug is a propylamine derivative?

UPSSSC Pharmacist (26.03.2023)

a. Diphenhydramine

b. Chlorpheniramine

c. Cyclizine

d. Pyrilamine

11 / 60

11. Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to_____

GPAT(09.04.2022)

a. Augment the anti‐motility action of Diphenoxylate

b. Suppress gastroenteritis‐related vomiting

c. Inhibits the side effects of Diphenoxylate

d. Discourage abuse of Diphenoxylate

12 / 60

12. Pilocarpine is______

HPSSC Pharmacist(22.08.2022)

a. Selective muscarinic receptor agonist

b. Non selective muscarinic receptor antagonist

c. Selective muscarinic receptor antagonist

d. Non selective muscarinic receptor agonist

13 / 60

13. Which of the following statements related to the location of drug information services/centre is INCORRECT?

MPSC Pharmacist (08.02.2023)

a. It should be near the pharmacy department.

b. It should be away from inpatient and outpatient departments.

c. It should be near the operation theatre.

d. It should be near the hospital library.

14 / 60

14. Choose the correct example of proton pump inhibitor.

UPSSSC Pharmacist (26.03.2023)

a. Alprazolam

b. Itraconazole

c. Pantoprazole

d. Albendazole

15 / 60

15. __________ are the agents that help in lowering increased lipid levels.

UP NHM Pharmacist (29.12.2022)

a. Antihypertensive drugs

b. Hypolipidemic drugs

c. Haematinics

d. Antidotes

16 / 60

16. How does phenylephrine differs from adrenaline?

UPSSSC Pharmacist (26.03.2023)

a. Lacking 4-COOH group on the benzene ring.

b. Lacking 4-NH group on the benzene ring.

c. Lacking 4-CONH2 group on the benzene ring

d. Lacking 4-OH group on the benzene ring.

17 / 60

17. The TDM refers to:

MPSC Pharmacist (08.02.2023)

a. Therapeutic Drug Monitoring

b. Therapeutic Dose Management

c. Therapeutic Dose Monitoring

d. Treatment Drug Monitoring

18 / 60

18. Match List I with List II, Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. 1:Q, 2:S, 3:P, 4:R, 5: T

b. 1:R, 2:Q, 3: S, 4: T, 5: P

c. 1:P, 2:Q, 3: T, 4: S, 5: R

d. 1:T, 2:Q, 3: R, 4:P, 5:S

19 / 60

19. Ivermectin exerts its anthelmintic action through:

MPSC Pharmacist (08.02.2023)

a. Leakage of intracellular Ca +2

b. Activation of nicotinic cholinergic receptors

c. Activation of glutamate gated ci- channel

d. Activation of glycine gated c1- channel

20 / 60

20. The following drug is dopaminergic agonist:

UPSSSC Pharmacist (26.03.2023)

a. Bromocriptine

b. Entacapone

c. Selegiline

d. Carbidopa

21 / 60

21. Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme

Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. All A, B, C and D are correct

b. Only A and B are correct

c. Only B is correct

d. A, B and D only are correct

22 / 60

22. An example of pyrazolone derivative analgesic is______

HPSSC Pharmacist(22.08.2022)

a. Phenylbutazone

b. Phenacetin

c. Mefanamic acid

d. Indomethacine

23 / 60

23. Adverse side effects of Selective Serotonin Reuptake Inhibitors like insomnia, increased anxiety, irritability and decrease libido are due to:

MPSC Pharmacist (08.02.2023)

a. Excessive stimulation of brain 5HT4 receptors

b. Excessive stimulation of brain 5HT2 receptors

c. (a) Excessive stimulation of brain 5HT1B receptors

d. Excessive stimulation of brain 5HT3 receptors

24 / 60

24. How many pharmacists are required for a 100-bed hospital?

UP NHM Pharmacist (29.12.2022)

a. 06

b. 05

c. 10

d. 02

25 / 60

25. Nitric oxide synthase exists in __________

GPAT(09.04.2022)

a. Four isoforms

b. Two isoforms

c. Five isoforms

d. Three isoforms

26 / 60

26. ____________ is the study of how the body interacts with administered substances for the entire duration of exposure.

UP NHM Pharmacist (29.12.2022)

a. Pharmacodynamics

b. Pharmacokinetics

c. Biotransformation

d. Bioactivation

27 / 60

27. Which of the following is a correct match of drug and its mechanism of action in the management of congestive heart failure?

MPSC Pharmacist (08.02.2023)

a. Torasemide - Afterload reduction

b. Dobutamine - Reduced heart rate

c. Hydralazine - Preload reduction

d. Levosimendan - Positive inotropic effect

28 / 60

28. Penicillin produces _____ upon hydrolysis with hot dilute inorganic acids.

HPSSC Pharmacist(22.08.2022)

a. Benzyl penicillin

b. Penicillamine

c. Pencilloic acid

d. Propicillin

29 / 60

29. Which antihypertensive drug is a direct renin inhibitor?

MPSC Pharmacist (08.02.2023)

a. Aliskiren

b. Moexipril

c. Phenoxybenzamine

d. Moxonidine

30 / 60

30. Pyrazinamide is______

HPSSC Pharmacist(22.08.2022)

a. Pyrazine-3-carboxamide

b. Pyrazine-2-carboxamide

c. Pyrazine-4-carboxamide

d. Pyrazine-1-carboxamide

31 / 60

31. Scientific research is the primary source of:

UP NHM Pharmacist (29.12.2022)

a. Review articles

b. Drug information

c. Database

d. Textbooks

32 / 60

32. An example of adsorbent is________

HPSSC Pharmacist(22.08.2022)

a. Magnesium stearate

b. Acacia

c. Magnesium silicate

d. Cellulose

33 / 60

33. Which of the following dye is used for the leakage test?

Lucknow Cantonment Board Pharmacist (05.02.2023)

a. Methylene blue

b. Methyl violet

c. Methylene rose

d. Methyl orange

34 / 60

34. Match List I with List II Match the following with their mechanism of action:

GPAT(09.04.2022)

a. A ‐IV , B ‐III , C ‐II , D ‐I

b. A ‐ II, B ‐ III, C ‐IV , D ‐I

c. A ‐II , B ‐V , C ‐III , D ‐IV

d. A ‐IV, B ‐ I, C ‐V , D ‐III

35 / 60

35. Which of the following drugs acts as ulcer protective agent?

MPSC Pharmacist (08.02.2023)

a. Ambroxol

b. Sucralfate

c. Cimetidine

d. Sodium citrate

36 / 60

36. The ‘Up‐and‐Down’ method for a projected LD50 determination is described in the…..

GPAT(09.04.2022)

a. OECD Guideline 420

b. OECD Guideline 423

c. OECD Guideline 401

d. OECD Guideline 425

37 / 60

37. A patient with pheochromcytoma is undergoing surgery and has not been administered with alpha receptor blocker. If he is administered with intravenous propranolol, then which of the following effects will be evident?

GPAT(09.04.2022)

a. The patient may suffer severe bronchoconstriction

b. There will be a fall in the blood pressure

c. The blood pressure will remain unchanged

d. There will be a rise in the blood pressure

38 / 60

38. Bitter metallic taste is characteristic of drug

HPSSC Pharmacist(22.08.2022)

a. Phenformin

b. Tetracycline

c. Glibenclamide

d. Mepyramine

39 / 60

39. Regarding Bromocriptine, which of the following statement is TRUE It is a relatively selective dopamine D2 agonist with prominent action
A. on pituitary lactotrophs (inhibit prolactin release)
B. in striatum (antiparkinsonian)
C. in CTZ (antiemetic)
D. as an adjunctive treatment for type 2 DM
Choose the correct answer from the options given below:

GPAT(09.04.2022)

a. A and B only

b. A, B and D only

c. A, B and C only

d. B and D only

40 / 60

40. Antihypertensive drugs are an example of:

UP NHM Pharmacist (29.12.2022)

a. standard dose

b. target level dose

c. regulated dose

d. titrated dose

41 / 60

41. Which of the following is not a screening method for antidiabetic agents?

UP NHM Pharmacist (29.12.2022)

a. Tooth pulp stimulation

b. Adrenaline-induced acute hyperglcaemia

c. Bio-breeding rat

d. Euglcaemic clamp technique

42 / 60

42. Which of the following is not an action of amphetamine?

HPSSC Pharmacist(22.08.2022)

a. Potent CNS stimulation

b. Increased mental and physical activity

c. Decreasing systolic and diastolic BP

d. Reduces appetite

43 / 60

43. __________ are drugs which treat rhinitis and other allergic conditions.

UP NHM Pharmacist (29.12.2022)

a. Antihistamines

b. Amphetamine

c. Antimicrobial agents

d. Penicillamine

44 / 60

44. General anaesthetics are_____ of the central nervous system.

UP NHM Pharmacist (29.12.2022)

a. Depressants

b. Stimulators

c. Activators

d. Stabilisers

45 / 60

45. Which of the following effect is produced by Saroglitazar?

MPSC Pharmacist (08.02.2023)

a. Decrease the glucose as well as lipid in plasma

b. Lowering the LDL in plasma

c. Lowering the LDL-CH in plasma

d. Increasing the HDL is plasma

46 / 60

46. Reduced bronchodilation by a beta2 agonist prescribed with a non-selective beta-blocker is an example of:

MPSC Pharmacist (08.02.2023)

a. Pharmacodynamic drug-drug interaction

b. Pharmacokinetic drug-drug interaction

c. Behavioural drug-drug interaction

d. Pharmaceutical drug-drug interaction

47 / 60

47. Which of the following drug is used in Herpes infection?

UPSSSC Pharmacist (26.03.2023)

a. Zidovudine

b. Efavirenz

c. Amantadine

d. Idoxuridine

48 / 60

48. Which of the following agents is NOT a teratogen?

MPSC Pharmacist (08.02.2023)

a. Tetracyciline

b. Streptomycin

c. Thalidomide

d. Amphotericin B

49 / 60

49. The following drug is acting by inhibition HMG-Co-A enzyme:

UPSSSC Pharmacist (26.03.2023)

a. Penicillin

b. Rosuvastatin

c. Fenofibrate

d. Streptokinas

50 / 60

50. Which of the following is not a muscarinic action of Acetylcholine?

HPSSC Pharmacist(22.08.2022)

a. Increase in tone and activity of smooth muscle

b. Vasodilation

c. Decrease in heart rate

d. Inhibition of gastric secretions

51 / 60

51. Which drug is an HIV protease inhibitor?

MPSC Pharmacist (08.02.2023)

a. Delavirdine

b. Acyclovir

c. Nevirapine

d. Lopinavir

52 / 60

52. In ADR, unusual and unexpected drug effects are known as:

MPSC Pharmacist (08.02.2023)

a. Idiosyncrasy

b. Excessive pharmacological effects

c. Secondary pharmacological effects

d. Allergic drug reactions

53 / 60

53. Which of the following is not an endogenous compound?

Lucknow Cantonment Board Pharmacist (05.02.2023)

a. Desipramine

b. Endorphins

c. Dopamine

d. Noradrenaline

54 / 60

54. Which enzyme catalyses the bioactivation of nitroglycerin into NO?

MPSC Pharmacist (08.02.2023)

a. Glycerol kinase

b. Aldehyde dehydrogenase 2

c. Glycerol dehydrogenase

d. Tyrosine kinase

55 / 60

55. Tendon rupture or tendonitis of Achilles tendon is an adverse reaction of:

GPAT(09.04.2022)

a. Aminoglycosides

b. Tetracyclines

c. Cephalosporins

d. Fluoroquinolones

56 / 60

56. Clofazimine is a/an _____derivative. Or Which of the following heterocyclic ring is present in Clofazimine which is used for the treatment of leprosy?

AMC Pharmacist (05.11.2023), HPSSC Pharmacist(12.12.2020)

a. Phenothiazine

b. Pyrazi

c. Phenazine

d. Azepine

57 / 60

57. Sympathetic blocking drug “guanethidine” acts by

HPSSC Pharmacist(22.08.2022)

a. By blocking adrenergic receptors

b. Depleting catecholamines

c. By interfering with synthesis of adrenergic transmitter

d. Interfering with transmission of impulse across postganglionic adrenergic neuron

58 / 60

58. The quadruple therapy of Helicobacter pylori infection includes:

GPAT(09.04.2022)

a. Bismuth subsalicylate, metronidazole, azithromycin and a proton pump inhibitor

b. Bismuth subsalicylate, metronidazole, tetracycline and a proton pump inhibitor

c. Sulfasalazine, metronidazole, tetracycline and a proton pump inhibitor

d. Streptomycin, metronidazole, tetracycline and a proton pump inhibitor

59 / 60

59. Bleeding due to displacement of warfarin from protein-binding sites is a type of ________ drug interaction.

UP NHM Pharmacist (29.12.2022)

a. oral antidiabetic

b. antihypertensive

c. analgesic

d. anticoagulant

60 / 60

60. Phenformin was withdrawn worldwide owing to high risk of:

MPSC Pharmacist (08.02.2023)

a. Lactic acidosis

b. Keto acidosis

c. Lactic alkalosis

d. Keto alkalosis

Your score is

The average score is 38%

Also, Visit:

B. Pharma Previous Year Question Paper

B. Pharma Handwritten Notes

B. Pharma PDF Books

B. Pharma Lab Manual

D. Pharma Lab Manual

B. Pharma 8th Semester Previous Year Question Paper

D. Pharma Notes

Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

Pharmacology and Toxicology Quiz Based on Previous Year Pharmacist Exam Paper Part 1

Leave a Comment Cancel reply