Erectile Dysfunction – B. Pharma 2nd Semester Pathophysiology notes pdf

Erectile Dysfunction


  • Erectile Dysfunction
  • Definition
  •  Causes
  •  Pathophysiology
  • Clinical Features


At the end of this PDF Notes, students will be able to –

       Define Erectile dysfunction

       Explain the Pathophysiology of ED

       Describe the clinical features of ED

Erectile Dysfunction (ED)

Erectile dysfunction is defined as “the failure to achieve a penile erection to allow for satisfactory sexual intercourse”

Patients may refer to it as impotence

Main Causes of Erectile Dysfunction

Causes of Erectile Dysfunction

Etiology of Erectile Dysfunction

  • Psychogenic
  • Vasculogenic : – Cardiovascular disease – Hypertension – Diabetes mellitus – Major surgery or radiotherapy (pelvis or etroperitoneum).
  • Neurogenic Central causes – Multiple sclerosis – Parkinson’s disease – Tumors – Stroke – Spinal cord disorders( disc disease ) Peripheral causes – Diabetes mellitus – Alcoholism – Polyneuropathy – Surgery (pelvis or retroperitoneum).
  • Anatomical/structural – Peyronie’s disease – Penile fracture – Congenital curvature of the penis
  • Hormonal – Hypogonadism – Hyperprolactinemia – Hyper-and hypothyroidism – Cushing’s disease.
  • Drug-induced – Antihypertensives (beta-blocker, thiazide and clonidine .less with ACE inhibitors ) – Antidepressants (tricyclic antidepressants and MAO inhibitor) – Antipsychotics – Antiandrogens – Antihistamines – Recreational drugs (Heroin and cocaine)

How Does Erection Normally Happen?

How Does Erection Normally Happen

Process of Erection

Process of Erection

Pathophysiology of Erectile Dysfunction

Pathophysiology of Erectile Dysfunction

Any single abnormality or combination of abnormalities of the four systems necessary for a normal penile erection

• Vascular, neurologic, or hormonal etiologies of erectile dysfunction are collectively referred to as organic erectile dysfunction

• Patients who do not respond to psychogenic stimuli have psychogenic erectile dysfunction

• Diseases that compromise vascular flow to the corpora cavernosum (e.g., peripheral vascular disease, arteriosclerosis, and essential hypertension) increases incidence of ED

• Diseases that impair nerve conduction to the brain (e.g., spinal cord injury or stroke) or conditions that impair peripheral nerve conduction to the penile vasculature

• Diseases associated with hypogonadism, primary or secondary, result in subphysiologic levels of testosterone, which cause diminished sexual drive (decreased libido) and secondary erectile dysfunction

• Vasoconstrictor effect of cigarette smoking may compromise blood flow to the corpora and decrease cavernosal filling

• Excessive ethanol intake may lead to androgen deficiency, peripheral neuropathy

Clinical Presentation of Erectile Dysfunction

Clinical Presentation of Erectile Dysfunction


       Erectile dysfunction is defined as “the failure to achieve a penile erection to allow for satisfactory sexual intercourse”

       It can occur due to various causes like psychogenic, vasculogenic and neurogenic

       Failure to initiate psychogenic or neurogenic impulse or failure to increase arterial blood pressure may result in ED

       ED may ultimately lead to impotence

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