Incompatibilities
q When two or more ingredients of a prescription
are mixed together, the undesired change that may take place in the physical,
chemical or therapeutic properties of the medicament is termed as
incompatibility.
q This is because of mixing 2 or more
antagonistic substances or formation of an undesirable product.
q It may affect the safety, efficacy and
appearance of the preparation.
Classification
q There are 3 types of incompatibilities:
– Physical incompatibilities
– Chemical incompatibilities
– Therapeutic incompatibilities
Physical incompatibilities
q When 2 or more antagonistic substances are
combined together, a physical change takes place and an unacceptable product is
formed due to immiscibility, insolubility or liquefaction
q The
changes are visible and can be corrected by the application of pharmaceutical
skill to obtain a product of uniform dosage, and attractive appearance
for detailed notes on Physical Incompatibilities click here
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