Pharmaceutics I – B. Pharma 1st Semester Notes

Scope:  Pharmaceutics 1st Semester Notes is designed to impart fundamental knowledge on the preparatory pharmacy with the arts and science of preparing the different conventional dosage forms.

Objectives: Upon completion of this course the student should be able to:

Know the history of the profession of pharmacy

Understand the basics of different dosage forms, pharmaceutical incompatibilities, and pharmaceutical calculations

Understand the professional way of handling the prescription

Preparation of various conventional dosage forms

Course Content: Pharmaceutics Notes 1st Semester

Pharmaceutics UNIT – I

Historical background and development of the profession of pharmacy: History of the profession of Pharmacy in India in relation to pharmacy education, industry, and organization, Pharmacy as a career,

Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.

Dosage forms: Introduction to dosage forms, classification, and definitions

Prescription: Definition, Parts of prescription, handling of Prescription, and Errors in prescription.

Posology: Definition, Factors affecting posology. Pediatric dose calculations are based on age, body weight, and body surface area.

Pharmaceutics UNIT – II

Pharmaceutical calculations:  Weights and measures – Imperial & Metric system, Calculations involving percentage solutions, allegation, proof spirit, and isotonic solutions based on freezing point and molecular weight.

Powders:  Definition, classification,  advantages and disadvantages, Simple  & compound powders – official preparations, dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures. Geometric dilutions.

Liquid dosage forms: Advantages and disadvantages of liquid dosage forms.

Excipients used in the formulation of liquid dosage forms. Solubility enhancement techniques

Pharmaceutics UNIT – III  

Monophasic liquids:  Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas, Syrups, Elixirs, Liniments, and Lotions.

Biphasic liquids:

Suspensions: Definition, advantages and disadvantages, classifications, Preparation of suspensions; Flocculated and Deflocculated suspension & stability problems and methods to overcome.

Emulsions: Definition, classification, emulsifying agent, test for the identification of the type of emulsion, Methods of preparation & stability problems, and methods to overcome.

Pharmaceutics UNIT – IV

Suppositories: Definition, types, advantages and disadvantages, types of bases, methods of preparations. Displacement value & its calculations, evaluation of suppositories.

Pharmaceutical incompatibilities: Definition, classification, physical, chemical, and therapeutic incompatibilities with examples.

Pharmaceutics UNIV – V

Semisolid dosage forms:  Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Preparation of ointments, pastes, creams, and gels. Excipients are used in semi-solid dosage forms. Evaluation of semi-solid dosages forms

pharmaceutics 1 notes pdf download

PHARMACEUTICS I (Practical)

1 . Syrups

a) Syrup IP’66

b) Compound syrup of Ferrous Phosphate BPC’68

2. Elixirs       

a) Piperazine citrate elixir

b) Paracetamol pediatric elixir

3. Linctus       

a) Terpin Hydrate Linctus IP’66

b) Iodine Throat Paint (Mandles Paint)

4. Solutions

a) Strong solution of ammonium acetate

b) Cresol with soap solution

c) Lugol’s solution

5. Suspensions

a) Calamine lotion

b) Magnesium Hydroxide mixture

c) Aluminum Hydroxide gel

6. Emulsions 

a) Turpentine Liniment

b) Liquid paraffin emulsion

7. Powders and Granules

a) ORS powder (WHO)

b) Effervescent granules

c) Dusting powder

D)Divded powders

8. Suppositories

a) Glycero gelatin suppository

b) Coca-butter suppository

c) Zinc Oxide suppository

8. Semisolids

a) Sulphur ointment

b) Non-staining-iodine ointment with methyl salicylate

c) Carbopal gel

9. Gargles and Mouthwashes

a)  Iodine gargle

b) Chlorhexidine mouthwash

Pharmaceutics Recommended Books: (Latest Editions)

1. H.C. Ansel et al., Pharmaceutical Dosage Form and Drug Delivery System, Lippincott Williams and Walkins, New Delhi.

2. Carter S.J., Cooper and Gunn’s-Dispensing for Pharmaceutical Students, CBS publishers, New Delhi.

3. M.E. Aulton, Pharmaceutics, the Science& Dosage Form Design, Churchill Livingstone, Edinburgh.

4. Indian pharmacopoeia.

5. British pharmacopoeia.

6. Lachmann. Theory and Practice of Industrial Pharmacy,Lea& Febiger Publisher, The University of Michigan.

7. Alfonso R. Gennaro Remington. The Science and Practice of Pharmacy, Lippincott Williams, New Delhi.

8. Carter S.J., Cooper and Gunn’s. Tutorial Pharmacy, CBS Publications, New Delhi.

9. E.A. Rawlins, Bentley’s Text Book of Pharmaceutics, English Language Book Society, Elsevier Health Sciences, USA.

10. Isaac Ghebre Sellassie: Pharmaceutical Pelletization Technology, Marcel Dekker, INC, New York.

11. Dilip M. Parikh: Handbook of Pharmaceutical Granulation Technology, Marcel Dekker, INC, New York.

12. Francoise Nieloud and Gilberte Marti-Mestres: Pharmaceutical Emulsions and Suspensions, Marcel Dekker, INC, New York.