ACECLOFENAC – Uses, Dosage, Pharmacology, Mechanism of Action, Side Effects, Contraindication & Interaction

 ACECLOFANAC 

ACECLOFENAC 

Aceclofenac

      
Aceclofenac is a nonsteroidal anti-inflammatory
drug (NSAID)

      
Analog of diclofenac

       It was patented in 1983 and approved for medical
use in 1992

USE

         
Rheumatoid Arthritis

         
Osteoarthritis

         
Ankylosing Spondylitis

         
Mild to moderate pain

         
Inflammation

DOSE

      
Adults – The recommended dose is 200 mg
daily, taken as two separate 100 mg doses, one tablet in the morning and one in
the evening.

      
Paediatric population – It is not
recommended for use in children under 18 years of age.

PHARMACOLOGY

      
Absorption – rapidly and completely
absorbed from the gastrointestinal tract

      
Volume of distribution – 25L

      
Protein binding – Highly protein-bound
(>99%)

      
Route of elimination – urine (70-80%),
feces (20%)

      
Half-life – approximately 4 hours

      
Clearance – 5 L/h 

MACHENISM OF
ACTION

      
Prostaglandins are substances which is
responsible for the sensation of pain, swelling, and inflammation.

      
Aceclofenac is a nonsteroidal anti-inflammatory
drug (NSAIDs) and works by blocking the activity of an enzyme that is
responsible for the formation of prostaglandins, thus relieving pain, swelling
and inflammation.

SIDE EFFECTS

      
Vomiting

      
Stomach pain/epigastric pain

      
Nausea

      
Indigestion

      
Diarrhea

      
Heartburn

      
Loss of appetite

PRECAUTIONS/CONTRAINDICATION

      
Allergies- Avoid if you have a known
allergy to Aceclofenac or other ANSIDs.

      
Asthma- Not recommended if you have been
diagnosed with asthma.

      
Bleeding – Aceclofenac is not recommended
if you have any bleeding disorder. It may cause severe swelling and bleed in
the stomach, colon, and anus.

      
Pregnancy- This medicine is not
recommended in pregnant women.

      
Breast-nutrition- This medicine is not
recommended for breastfeeding women.

      
Gastrointestinal bleeding- Cause severe
bleeding when taken for a long time. Elderly populations with a history of
gastrointestinal disease are at higher risk.

      
Cardiac surgery- Not be used to relieve
pain before or after CABG (coronary artery bypass surgery).

      
Kidney- Not recommended if you have
impaired kidney function.

      
Liver- Use with caution with an initial
dose of 100 mg once daily for mild liver failure. Contraindicated in the severe
failure of the liver.

Interaction
with Medicine

      
Corticosteroids – Moderate

      
Antihypertensives – Severe

      
Digoxin– Severe

      
Warfarin– Severe

      
Lithium– Severe

FAMOUS
BRANDS

BRAND NAME

COMPANY

MRP

ZERODOL TABLETS

IPCA

51.45

HIFENAC TABLETS

INTAS

52.00

DOLOKIND 100MG TABLETS

MANKIND

32.10

ACECLO TABLETS

ARISTO

48.00

ACENAC TABLETS

MEDLEY

45.50

MOVON TABLETS

IPCA

41.10

DOLOWIN TABLETS

MICRO

51.00

ACENEXT 100MG TABLETS

CADILA

24.50

ACEMIZ 100MG TABLETS

LUPIN

67.00

DOLOSTAT 100MG TABLETS

BLUE CROSS

35.00

EQUIDOL 100MG TABLETS

AKUMENTIS

75.00

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