Contents
• Emetics
• The monograph analysis of:
Copper sulphate
Antimony potassium tartarate
Learning
Objectives
At the end of this
lecture, the student will be able to:
• Define: Emetics
• Explain the monograph analysis of:
Copper sulphate
Antimony potassium tartarate
Emetics
Definition:
Emetics are the agents which induces vomiting. Used for treating poisoning
cases
Mechanism of action:
• They may act directly on the gastrointestinal tract
bringing about emesis through local irritation effect. Ex: ammonium carbonate
• They may act indirectly through their effect on the
vomiting centre or chemo recptor trigger zone postermal area near the medulla.
Ex: Copper sulphate and Antimony potassium tart rate
Monograph
of Copper Sulphate
Name: Copper
Sulphate
Chemical formula:
CuSO4 5H2O
Molecular weight:
249.7
Standard: Copper
sulphate contains not less than 98.5 per cent and not more than 101.0 per cent.
Synonym: Cupric
sulphate, Blue vitriol
Method of
preparation:
2Cu + 2H2SO4 + O2 → 2CuSO4
+2H2O
Properties of Copper
sulphate:
Description: Deep
blue, triclinic crystals, soluble water in water
Assay: Redox,
Iodometric titration
CuSO4 + 2KI → CuI2 + K2SO4
2CuI2 ßàCu2I2
+ I2
I2 + Na2S2O3 → 2NaI + Na2S4O6
Cu2I2 + 2KSCN→ 2CuSCN + 2NaI
Indicator: Starch
Colour change:
Blue to colorless
Medicinal uses:
• Emetics
• Antidote for Phosphorus poisoning
• Astringent and as fungicide
Storage: store
protected from light and moisture
Monograph
of Antimony potassium tartarate
Name: Antimony
potassium tartarate
Chemical formula:
C4H4KO7Sb
Molecular weight:
333.93
Standard: It
contains not less than 99.0 per cent and not more than 103.0 per cent.
Synonym: Tarter
emteic
Method of
preparation:
KHC4H6O6 + Sb2O3
→ C4H4KO7Sb + H2O
Properties of
Antimony potassium tartarate:
Description:
Colorless crystals, efflorescent, sweet in taste, odourless, soluble in water
and insoluble in alcohol
Medicinal uses:
• Emetics
Storage: store in
a well-protected containers