Senna and Anthracene Glycosides – Source, diagnostic characters, constituents and uses of Senna

Anthracene Glycosides

Content

Source, diagnostic characters, constituents and
uses of Senna

Objectives

At the
end of this lecture, student will be able to

Discuss the source, diagnostic characters,
constituents and uses of Senna

Anthracene glycosides

• Major class of glycosides

• Dicots – Euphorbiaceae, polygonaceae, Rhamnaceae,
rubiaceae etc

• Monocots – Liliaceae

• Fungi and lichens

• Lower plants – bryophytes, pteridophytes and gymnopserms –
devoid of glycosides

• Aglycone – Anthraquinone, anthrone, anthranol,
dianthranol, oxanthrone, dianthrone

• In some cases – derived form – Senna, aloe, rhubarb,
cascara, etc

• Reduced form – anthraquinone as anthranol (brownish
yellow) or anthrone (Plae yellow)

Borntrager’s test

• Anthraquinone glycosides

• Drug + Organic solvent – Organic layer made alkaline with
caustic soda or ammonia, aqueous layer shows pink, red or violet colour

Anthranol – reduced form negative for borntrager’s test

Senna

Synonym

• Tinnevely senna, Alexandrain senna, Folia senna, Senna
leaf, Cassia senna

Source

• Dried leaflets of Cassia angustifolia (Indina
senna) and Cassia acutifolia (alexandrain senna)

Family

• Leguminosae

Morphology of Senna

• Type

• Colour

• Shape

• Size

• Odour

• Taste

• Petiole

• Margin

• Apex

• Base

• Venation

• Texture

Microscopy of Senna

• Paracytic stomata

• Covering trichome

• Isobilateral

• Lamina

• Upper epidermis

• Mesophyll

• Upper palisade

• Spongy parenchyma

• Lower palisade

• Lower epidermis

• Midrib

• Epidermal layers are continuous in the midrib

• Lower palisade is not in the midrib

• Collateral type

• Sclerenchymatous fibres

• Crystal sheath

Microscopy of Senna

Powder Characters of Senna

Organoleptic characters: Taste, Colour, odour, taste

• Covering trichome (unicellular)

• Paracytic stomata

• Calcium oxalate (Cluster/prisms)

• Epidermal cells

• Mesophyll

Active Constituents

• Glycosides: Anthracene – Dianthrone glycosides

                                                Sennoside
A

                                                Sennoside
B Homodianthrones

                                                Sennoside
C

                                                Sennoside
D Heterodianthrones

• Rhein, emodin, aloe emodin- aglycones

• Flavonoid- Kaempferol glycoside

Use

• Laxative in case of habitual constipation

Summary

• Senna is an isobilateral leaf

• Lamina is differentiated into upper epidermis, upper
palisade, spongy parenchyma, lower palisade and lower epidermis

• In midrib, the upper palisade in continuous whereas lower
palisade is interrupted with collenchyma

• Crystal sheath and sclerenchymatous sheath are found in
the midrib

• Senna contains anthracene types of glycosides

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