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Medicinal Chemistry Quiz 1: Exploring the World of Drug Discovery

Medicinal chemistry is an intriguing field that plays a vital role in the development of new drugs. It combines chemistry and pharmacology to design and discover effective medications that can improve and save lives. If you’re interested in learning more about this fascinating subject, what better way than to test your knowledge through a Medicinal Chemistry Quiz?

Medicinal Chemistry Quiz 1:

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Medicinal Chemistry-I Unit -1 25 Important MCQs

Medicinal Chemistry-I Unit -1 25 Important MCQs quiz helps us to increase our knowledge

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1 / 25

1. The most abundant plasma protein Is?

a. Lipoprotein

b. Glycoprotein

c. Globulin

d. Albumin (Human serum albumin)

2 / 25

2. Which of the intermolecular bonding interactions below are possible for an alcohol?

a. Hydrogen bonding only

b. Both hydrogen bonding and ionic bonding

c. van der Waals interactions only

d. Ionic bonding only

3 / 25

3. Which of the following characteristics is unfavorable to oral activity?

a. susceptibility to metabolic enzymes

b. solubility in both aqueous and fatty environments

c. stability to stomach acids

d. stability to digestive enzymes

4 / 25

4. Absorption of Tetracycline is reduced in the presence of milk because of

a. Lonization

b. Hydrogen bonding

c. Protein binding

d. Chelation

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5. Which one of the following factor related to protein-drug binding is not related to drug Interactions with the binding site?

a. Competition between drugs and normal body constituents

b. Competition between the drug and the binding site

c. Inter subject variation

d. Allosteric changes in a protein molecule

6 / 25

6. Which ester of Chloramphenicol is prepared to mask Its bitter taste?

a. Palmitate

b. Hydrochloride

c. Sodium

d. Salicylate

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7. Which of the following statements best describes structure-activity relationships (SAR)?

a. The study of the structural features of a drug that are important to its chemical stability.

b. The study of the physicochemical properties that are important to the absorption of a drug into the blood supply.

c. The study of the structural features of a drug that are important to its biological activity.

d. The study of which functional groups are important to the chemical reactivity of the drug.

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8. Which of the following reactions is not a Phase I metabolic transformation?

a. conjugation to alcohols

b. oxidation of alkyl groups

c. reduction of ketones

d. ester hydrolysis

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9. Which one of the following factors related to protein-drug binding is not related to drugs?

a. The concentration of the drug in the body

b. The affinity of the drug for binding

c. Physicochemical characteristics of a drug

d. Number of binding sites on the binding agent

10 / 25

10. For most of the chiral drugs, which enantiomer is more active?

a. R isomer

b. S isomer

c. Always their racemic mixture

d. It can’t be generalised

11 / 25

11. Only unbound or free drug is capable of being eliminated.

a. False

b. Drugs never eliminated

c. Cant say about this

d. True

12 / 25

12. Which of the following statements is the closest description of Phase I metabolism?

a. Reactions which occur in the blood supply.

b. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.

c. Reactions which occur in the gut wall.

d. Reactions which add a polar functional group to a drug.

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13. Plasma proteins bound with drugs by formation of

a. Vander-waal’s force / Ionic interaction

b. All of the above

c. Hydrophobc bonding

d. Hydrogen bonding

14 / 25

14. Functional groups of same valance and ring equivalents are known as

a. Non- Classical Bioisosteres

b. Geometrical isomers

c. Classical Bioisosteres

d. Enantiomers

15 / 25

15. Which of the following is not primary but derived pharmacokinetic parameter

a. Distribution volume

b. Bioavilability

c. Clearance

d. Plasma half life

16 / 25

16. Chelating agent Dimercaprol is used in the treatment of

a. All of above

b. Lead poisoning

c. Vanadium poisoning

d. Arsenic poisoning

17 / 25

17. Which of the following enzymes is not involved in catalysing a Phase I metabolic reaction?

a. Glucuronyltransferase

b. Monoamine oxidases

c. Esterases

d. Flavin-containing monooxygenases

18 / 25

18. In Lead and vanadium poisoning, which chelating agent Is used as an antidote?

a. Dimercaprol

b. Cyanocobalamine

c. Disodium EDTA

d. Haemoglobin

19 / 25

19. D-Asparagine has sweet taste while L-Asparagine has…….. Taste

a. Sweet

b. Tasteless

c. Bitter

d. Sour

20 / 25

20. The most significant protein Involved In binding with a drug is

a. Lipoprotein

b. Globulin

c. Glycoprotein

d. Albumin

21 / 25

21. What is common in Warfarin, propranolol, ketamine and amphetamine

a. S configuration is more active than R configuration

b. None

c. both

d. R configuration is more active than S configuration

22 / 25

22. Methyl Prednisolone and Phenobarbitone are water Insoluble but its which salt is water soluble?

a. Hydrochloride

b. Salicylate

c. Sodium

d. Palmitate

23 / 25

23. Which of the following statements is the closest description of Phase II metabolism?

a. Reactions which occur in the gut wall.

b. Reactions which occur in the blood supply.

c. Reactions which add a polar functional group to a drug.

d. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.

24 / 25

24. (+) Sotalol is beta blocker while (-) Sotalol is

a. beta blocker

b. Analgesic

c. Antidepressant

d. Antiarrhythmic

25 / 25

25. Which of the following factors for protein drug binding is a drug Interaction factor?

a. Competition between drugs for the binding site

b. Age

c. Physicochemical characteristics of the protein or binding agent

d. Physicochemical characteristics of a drug

Your score is

Frequently Asked Questions (FAQs)

What is Medicinal Chemistry, and why is it important?
- Medicinal Chemistry is the branch of science that deals with the design and development of pharmaceutical agents, such as drugs. It is crucial for creating effective medications that treat various medical conditions and improve healthcare.
What are the fundamental principles of Medicinal Chemistry?
- The fundamental principles of Medicinal Chemistry include the structure-activity relationship (SAR), which explores how the chemical structure of a compound affects its biological activity. Additionally, it involves drug design, synthesis, and the study of pharmacological properties.
How can I prepare for a Medicinal Chemistry exam or quiz effectively?
- To prepare effectively, focus on mastering the basics, using reliable study materials, managing your time wisely, and practicing with quizzes or sample questions. Effective note-taking and self-assessment are also key strategies.
What career opportunities are available for those with expertise in Medicinal Chemistry?
- Medicinal Chemistry experts can pursue careers as medicinal chemists, pharmaceutical researchers, drug developers, or work in pharmaceutical companies, research institutions, and regulatory agencies.
Where can I find additional resources for learning Medicinal Chemistry?
- You can find additional resources in libraries, online educational platforms, textbooks, and research journals. Many universities and institutions offer online courses or lectures related to Medicinal Chemistry for in-depth learning.

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