The Pyruvate kinase exerts glucokinaseindependent effects on insulin secretion pathways in Bcells. An exciting finding is that, by stealing the ADP required for oxphos, Pyruvate Kinase toggles mitochondria between ATP generation and PFP biosynthesis.

The nervous system is made up of neurons, specialized cells that can receive and transmit chemical or electrical signals and glia cells that provide support functions for the neurons by playing an information processing role that is complementary to neurons.

10 (1–x) laminae are present in the grey matter of spinal cord. Structure of brain & spinal cord are arranged in two layers namely grey matter & white matter. Grey matter is formed by neuron cell bodies (soma). Grey matter present in outer surface of cerebrum & cerebellum.
• In brain stem grey matter is located in groups of neurons called nuclei, embedded with white matter tracts. (Ex→ Basal ganglia)
• Grey matter is the outer parts of the brain & inner parts of the spinal cord but white matter is present in inner part of brain & outer part of spinal cord.

Heart failure, also known as congestive heart failure is a condition that develops when your heart doesn’t pump enough blood for our body's needs this can happen if our heart can fill up with enough blood. It can also happen when our heart is too weak to pump properly.
→ Angina pectoris is the medical term for chest pain or discomfort due to coronary heart disease.
→ sudden cardiac death (SCD) is by unexpected and cardiac in nature.

In central nervous system, the nerves that arise from cerebrum and brain stem are called as cranial nerves. The cranial nerves are a set of 12 paired nerves in the back of our brain cranial nerves send electrical signal to our brain. Face, neck and torso. Our cranial nerves help us taste smell, hear and fell sensations. These also help us to make facial expressions, blink our eyes and move our tongue.

Dopamine, adrenaline and noradrenalin are all catecholamine's.
• Catecholamine's are hormones that the brain, nerve tissue, and adrenal glands produce.
• The body releases catecholamine's in response to emotional or physical stress.
• Catecholamine's are responsible for the body's "fight or flight" response.

Cerebrosides the simplest neutral glycolipids/ glycosphingolipids have a single sugar that is linked to ceramide.

Inulin clearance is measure of Glomerular filtration rate. Glomerular filtration is the process that takes place in the kidney. It is a process that involves the filtration of blood and the removal of waste takes place.
GFR=Pinulin/Uinulin(Vu)

Where,
Uinulin = Concentration of inulin in the urine.
Pinulm = Concentration of inulin in plasma.
Vu = Urine flow rate.

hn RAN stands for heterogenous nuclear RNA. It refers to the large pre - mRNAs of various nucleotide sequences II and processed in the nucleus to become cytoplasmic mRNAs .
• The hn RNA that is associated with proteins from the heterogenous nuclear ribonucleoprotein ( hn RNP)

Creatinine clearance is used as a measurement of Glomerular Filtration Rate(GFR). The creatinine clearance test helps provide information about how well the kidneys are working. The test compares the creatinine level in urine with the creatinine level in blood. This test requires both a urine sample and blood sample.

The initial portion of the aorta ascending behind the sternum is referred to as the ascending aorta extends approximately to the level of the T4 vertebral body. From this point, it is known as the aortic arch.

Miglitol is an oral alpha-gluconsidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrate. Miglitol inhibits the breakdown complexes carbohydrate in to glucose. Miglitol is used to treat high blood sugar levels that are caused by type 2 diabetes.

Vitamin A is a precursor of rhodopsin, the photo pigment found in rods within retina of our eye that helps us to see at night. Without vitamin A, "night blindness' occurs. vitamin A is a fat soluble vitamin and found in many supplements and foods. Rhodopsin also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor.

Bile is a physiological aqueous solution product and secreted by the liver. It consists mainly of bile salts phospholipids, cholesterol, conjugate billirubin electrolytes and water bile travels through the liver in series of ducts. Eventually exiting through the common hepatic duct.

The sternum is a partially T. Shaped vertical bone that forms the anterior portion of the chest wall centrally. The sternum of the sternum is divided anatomically into three segments.
The sternum connects the ribs via the costal cartilages forming the anterior rib cage.

The hepatic vein carried the blood away from the inferior vena cava, which leads to the right atrium, one
of the four chambers of the heart.
• They are usually there- RHV, MHV and LHV.
• Vena cava is the largest vein in the body.

A heart arrhythmia is an irregular heartbeat. Heart rhythm problems occur when the electrical signals that coordinate the hearts beats don't work properly. The faulty signaling causes the heart to beat too fast or irregularly.
• In general , heart arrhythmias are grouped by the speed of the heart rate, for example -
• Tachycardia is a fast heart. The resting heart rate is greater than 100 beats a minute.
• Bradycardia is a slow heartbeat. The resting heart rate is less than 60 beats a minute.

The creatinie clearance (crcl) rate approximates the calculation of Glomerular filtration rate (GFR) since the glomerulus freely filters creatinine. However it is also secreted by the per tubular capillaries causing crcl to overestimate the GFR by approximately 10% to 20%

metabolism of salicylates occurs through glucuronidation and by conjugation to salcyluric acid. Liver metabolizes salicylates by first order elimination, and the inactive metabolites are then excreted in the urine.

Melatoninn is a hormone secreted by the enigmatic pineal gland in response to darkness, hence named as the hormone of darkness.
• The pineal gland, conarium or epiphysis cerebri, is a small endocrine gland in the brain of most vertebrates.
• Melatonin found in plants and animals. It is primarily known in animals as a hormone.

IN NREM Sleep Dorsal raphe nucleus in not involved.
• NREM sleep involves a reduce heart rate, lower blood

• The dorsal raphe nucleus is located on the midline of the brainstem and in one of raphe nucleus. It has rostral and caudal subdivisions. The dorsal raphe in the largest serotonergic nucleus and provides a substantial proportion of the serotonin inneruation to the forebrain.

Cancer cells:-
• Grow in the absence of signals telling them to grow.
• Ignore signals that normally tell cell to stop dividing or to die invade into nearby areas and spread to other areas of the body.
• Hide from the immune system, that normally eliminates damaged or abnormal cells.
• Trick the immune system into helping cancer cells stay a Live and grow.
• Mutations destroy telomerase intibitor.

Endothelium dependent relaxing factor of blood Nitric oxide. Endothelium dependent relaxation occurs in resistance vessels as well as in larger arteries and is generally more pronounced in arteries platetet aggregation and adhesion to the blood vessel wall.

Thromboxane is mainly synthesized by platelets. Thromboxanes, a substance produced by platelets, lead to occlusion of blood vessel by fueling blood clots inside the vascular system, this has been implicated in many cardiovascular conditions ranging from heart attack to stroke.

An organ or structure that is not a component of the urinary system is the Adrenal gland. The urinary system consists of ureters, kidneys, nephrons, urinary bladder, and urethra.
• The ureter is a small tube, or duct that connects the bladder and kidneys. urine passes through the ureter from the kidneys to the bladder, the urethra is the tubular path that connects the bladder to the body's exterior, allowing urine to exit the body.

Iodine-123 (or I-123) is a radio-isotope of iodine used for evaluation of the thyroid function and morphology. It is used in nuclear medicine for the diagnostic study of thyroid disease.

The spleen is part of our lymphatic system. The spleen is a fist-sized organ found in the upper left side of our abdomen, next to our stomach and behind our left ribs. We can survive without it but it is an important part of our immune system.

The human serum albumin is the most abundant protein in the human body. The molecular weight of human serum albumin is 65,000 Dalton.

The juxt-aglomerular cells are stimulated to secrete renin by three mechanism, all of which are activated in response to decreased extracellular fluid volume. Macula densa cells stimulate Juxtaglomerular cells to release renin when they detect a drop in sodium concentration in the tubular fluid.

Acute gastritis Type of food poisoning is caused by staphylococcus aureus. Staph food poisoning is a gastrointestinal illness caused by eating foods contaminated with toxins produced by the bacterium staphylococcus aureus staph bacteria.

Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins .
• The activation of plasma kallikrein - kinin leads to the activation of several sequential effector proenzymes resulting in the induction of genes and activation of biomolecules involved in the molecular mechanisms of vasodilation , blood coagulation and fibrinolysis.

Erythropoietin (EPO) is a glycoprotein hormone, naturally produced by the peritubular cells of the kidney, that stimulates red blood cells production. Renal cortex peritubular cells produce most EPO in the human body. PO2 directly regulates EPO production. The lower the PO2. the greater the production of EPO.

In a healthy person the GFR is about 125 ml/min, which makes 180 liters per day.

Largest organ is the body is skin. It can seem counterintuitive since many of our other organs are unseen. The skin, made up of three of the layers the Epidermis the Dermis and hypodermis is an external organ.

Pepsin is used in cheese manufacturing as substitute of rennin. The key & characteristics step in the manufacture of rennet coagulated cheeses is the coagulation of milk through the limited proteolytic action certain proteinases, called rennnets. Several proteinases can coagulate milk but only a few are suitable for cheese production. This led to a search for rennet substitute, four of which are commercially successful: bovine, pepsin and proteinases from the fungi R. meihei, R. pusillus and C. parasitic. All successful rennet substitutes are aspartyl (acid) proteinases.

Ependymocytes are one of the three types of ependymal cells which in turn are one of the four principles types of glial cells, and are found lining ventricular system of the brain and the central canal of the spinal cord.

• Astrpcutes are specialized glial cells that outnumber neurons by over fivefold, they contiguously tile the entire CNS and exert many essential complex functions in the healthy CNS.
• Oligodenrocytes - These are the myelinating cells of CNS.
• Podocytes→ podocytes are terminally differentiated cells of the kidney glomerulus that are essential for the integrity of the kidney filter.