They act by neutralizing Gastric acid in the stomach.
Mechanism of action
They achieve their effects by neutralizing gastric acid,
inhibiting gastric acid secretion or protect gastric mucosa.
Drug example and
1 Sodium bi carbonate – 1-5 gram orally
2 Magnesium hydroxide – 0.5-1gm
3 Aluminum Hydroxide – Up to 1gm daily
4 Magnesium carbonate – 250-500 mg orally
5 Calcium carbonate – Up to 1.5gm daily
Indications / Uses
Pain and burning with peptic ulcer.
Abdominal pain of unknown origin.
Caution in renal failure because they contain magnesium.
Constipation (Aluminum Hydroxide).
Hypophosphatemia (with Aluminum Hydroxide).
Hypomagnesemia (with Magnesium Hydroxide).
Increase sodium can cause edema and CHF. (Sodium bi
Diarrhea (Magnesium Hydroxide)
Antacids decrease absorption of anticholinergics,
sucralfate, H 2 receptor antagonists, Iron, Isoniazid and Tetracyclines.
Antacids Notes PDF