SOP on Calibration of Karl Fischer Apparatus

 Calibration of Karl Fischer Apparatus

 

1.0
PURPOSE

 The purpose of the standard operating procedure is
to provide guidelines   for calibration
of Karl

 Fischer
Apparatus..

 2.0 SCOPE   

 The
scope of this standard operating procedure includes calibration of Karl Fischer
Apparatus.

3.0 RESPONSIBILITY

3.1   Application
Scientist

3.2   QA Manager

3.3  Director Technical

4.0  PROCEDURE

4.1 APPARATUS REQUIRED FOR
CALIBRATION:

      Dried Beakers, which have been previously
rinsed with acetone. 

      Calibrated Analytical Balance

4.2 DETERMINATION OF VOLUME:

Clean the measurement/dispensing pipette available with
the respective set of the equipment.

Fill the measuring pipette with water and adjust to the
zero point.

Dispense the known volumes of water at random or from the
set point of the graduation marks of the pipette.

Repeat the dispensing of water at different set points
and weigh the beaker again and again.

From the different weights obtained calculate the volume
dispensed and co-relate with the graduation of the pipette and assign the value.

4.3 CALCULATION:

                                                            Weight
of the water dispensed (gm)

        Volume of the pipette (ml), V= ————————————————–

                                                            Density
of Water at 27oC (gm / ml)

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