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Hemophilia

Contents hide

Contents

• Clotting and clotting factors

• Hemophilia

• Hemophilia A and Hemophilia B

OBJECTIVE

At the
end of the PDF Notes, the students will be able to

• Explain hemophilia

• Describe the pathophysiology and
clinical features of Hemophilia

• Describe the clinical features and
treatment of Haemophilia a and Haemophilia b

Normal Clotting

Response to
vessle injury

1.
Vasoconstriction to reduce blood flow

2. Platelet
plug formation (von willebrand factor binds damaged vessle and platelets)

3.
Activation of clotting cascade with generation of fibrin clot formation

4.
Fibrinlysis (clot breakdown)

Normally
the ingredients, called factors, act like a row of dominoes toppling against
each other to create a chain reaction.

If one of the factors is missing this chain reaction cannot proceed.