Hemophilia – B. Pharma 2nd Semester Pathophysiology notes pdf

Hemophilia

Contents

       Clotting and clotting factors

       Hemophilia

       Hemophilia A and Hemophilia B

OBJECTIVE

At the
end of the PDF Notes, the students will be able to

       Explain hemophilia

       Describe the pathophysiology and
clinical features of
Hemophilia

        Describe the clinical features and
treatment of Haemophilia a and Haemophilia b

Hemophilia

Normal Clotting

Response to
vessle injury

1.
Vasoconstriction to reduce blood flow

2. Platelet
plug formation (von willebrand factor binds damaged vessle and platelets)

3.
Activation of clotting cascade with generation of fibrin clot formation

4.
Fibrinlysis (clot breakdown)

Clotting Cascade

Normally
the ingredients, called factors, act like a row of dominoes toppling against
each other to create a chain reaction.

If one of the factors is missing this chain reaction cannot proceed.




















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