Anthelmentics

Anthelmentics

Introduction:

Tropical diseases caused by parasitic
worms (multicellular organism) which infest the body are called as helminth.

The three main families of worms that
infest human being belong to two phyla.

1. Nematodes /nemathelminthes (round worm)

2. Platyhelminthes

i) Cestodes  (tape worm )

ii)Trematodes

Most of the
people carry one or another type of parasite in intestine .among the nematodes,
hook worm causes dangerous infestation as they remains attached to wall of
intestine and suck the blood.

Other nematode
infection are following

i) Safaris (round worm)

ii)Thread worm

iii) Whip worm

iv) Guinea worm

v) Pin worm

vi)Trichinosis

Cestodes are
unpleasant but do not cause serious illness.

The
Trematodes infestations contributing to death is Schistomiasis (blood flukes or
bilharzias) is when penetrating the unbroken skin to veins and causing slow
destruction of liver and kidney.

This parasite
cause abdominal pain, anorexia, diarrhea with blood and mucus, enlarged liver

Definition: – Anthelmentics are the drugs which are used to combat (appose) any type of
helminthiasis (Helmenthic infections)

Classification of Anthelmentics:-

1. Halogenated
hydrocarbon:
-e.g. Tetrachloroethylene.

2. Halogenated
phenol and biphenyl
:-e.g. Bithinol

3. Dyes: – Gentian
violet

4. Piperazine
and related compound
:-e.g. Piperazine citrate, DEC.

5. Other
heterocyclic ring containing compound:
-E.g.Mebendazole, (benzimidazole) niridazole
(imidazole).

6. Alkaloids:
– e.g.-Emetine

7. Antimonial
compound:
-e.g. –Antimony Potassium Tartarate

Piperazine

Structure of Piperazine: