Applications of Pharmacokinetics
Applications of Pharmacokinetics
Session objectives
By the end of this session, students will be able to:
- Define and explain the dosage regimen
- Discuss the individualization of drug therapy
Dosage size
- The magnitude of both therapeutic and toxic responses depends upon dose size
- Dosage size calculation also requires the knowledge of the amount of drug absorbed after administration of each dose
- Greater the dose size, the greater the fluctuation between Css,max and Css,min during each dosing interval, and the greater the chances of toxicity
- For drugs administered chronically, dose size calculation is based on average steady-state blood level and is computed as an equation
Xss,av = 1.44FX0t1/2/ז
Dosing frequency
• The dose interval (inverse of dosing frequency) is calculated on the basis of the half-life of the drug.
• If the interval is increased and the dose is unchanged Cmax, Cmin and Cav decrease but the ratio Cmax /Cmin increases.
- The Opposite is observed when the dosing interval is reduced or the dosing frequency increased
- Also results in greater drug accumulation in the bodyàtoxicity
- A proper balance between both dose size and dosing frequency is often desired to attain steady-state concentration
Individualization of Drug Dosage Regimens
Therapeutic Drug Monitoring: In administering potent drugs to patients, the physician must maintain the plasma drug level within a narrow range of therapeutic concentrations
The functions of a TDM service are listed below:
- Select drug
- Design dosage regimen
- Evaluate patient response
- Determine the need for measuring serum drug concentrations
- Assay for drug concentration in biological fluids
- Perform pharmacokinetic evaluation of drug concentrations
- Readjust dosage regimen, if necessary
- Monitor serum drug concentrations
Drug Selection
- The choice of drug and drug therapy is usually made by the physician
- Pharmacokinetics and pharmacodynamics are part of the overall considerations in the selection of a drug for inclusion into the drug formulary (DF)
- Drugs with similar therapeutic indications may differ in dose and Pharmacokinetics
Dosage Regimen Design
- The overall objective of dosage regimen design is to achieve a target drug concentration at the receptor site
- The usual pharmacokinetics of the drug—including its absorption, distribution, and elimination profile—are considered in the patient
- Pathophysiologic conditions, such as renal dysfunction, hepatic disease, or congestive heart failure, may change the normal pharmacokinetic profile of the drug and the dose must be carefully adjusted
Drug Dosage Form (Drug Product):
- Affect drug bioavailability
- The rate of absorption
- The route of drug administration and the desired onset will affect the choice of drug dosage form
Patient Compliance:
- Cost of the medication
- Complicated instructions
- Multiple daily doses
- Difficulty in swallowing
- Adverse drug reactions
Evaluation of Patient’s Response
- The practitioner should evaluate the patient’s response clinically
- If the patient is not responding to drug therapy as expected, then the drug and dosage regimen should be reviewed
Measurement of Serum Drug Concentrations
- A major assumption made by the practitioner is that serum drug concentrations relate to the therapeutic and/or toxic effects of the drug
- A single blood sample gives insufficient information. Several blood samples are often needed to clarify the adequacy of the dosage regimen
- The pharmacokinetic should be aware of the usual therapeutic range of serum concentrations from the literature.
Dosage Adjustment
- The new dosage regimen should be calculated using the pharmacokinetic parameters derived from the patient’s serum drug concentrations
Steps Involved in Individualization of Dosage Regimen
- Estimation of Pharmacokinetic parameters in individual patients & determining their deviation from the population values to evaluate the extent of Variability
- Attributing the variability to some measurable Characteristics such as Hepatic or Renal disease, Age, Weight, etc.
- Designing the new dosage regimen from collected data
Dosing of Drugs in Obese Patients
- IBW (men) = 50 Kg + 1Kg/2.5 cm above or below 150 cm in height
- IBW (women) = 45Kg +1 Kg/2.5 cm above or below 150cm in height
- Any person whose body weight is more than 25% above the IBW is considered obese
Dosing of Drugs in Neonates, Infants & Children
Mosteller’s equation:
SA (in m2) = (height X weight)1/2/60
- A child’s maintenance dose can be calculated from the adult dose by using the following equation :
Child’s dose= SA of Child in m2 X Adult Dose/1.73
SA (in m2) = Body weight (Kg)0.7
Monitoring drug therapy
- Depending upon the drug and the disease to be treated, management of drug therapy in individual patients can be accomplished by:
- Monitoring therapeutic effect-therapeutic monitoring
- Monitoring pharmacologic actions-pharmacodynamic monitoring
- Monitoring plasma drug concentration –pharmacokinetic monitoring
Summary
- The search for new drugs can be divided functionally into two stages: discovery and development
- Application of pharmacokinetics are Drug Development, Formulation Development Deciding Dosage Regimen, Designing Rational Dose, Frequency, and Duration In Vitro –In Vivo correlation studies and Pharmacokinetics, Pharmacodynamics Relationship
- Therapeutic Drug Monitoring is administering potent drugs to patients, the physician must maintain the plasma drug level within a narrow range of therapeutic concentrations
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