Packaging materials in pharmaceutical industry

Packaging Materials in Pharmaceutical Industry

Packaging Materials in Pharmaceutical Industry

Packaging Materials in Pharmaceutical Industry

  • Packaging is the science, art and technology of enclosing or protecting products for distribution, storage, sale, and use.
  • Packaging also refers to the process of design, evaluation, and production of packages.
  • Pharmaceutical packaging can be defined as the economical means of providing presentation, protection, identification, information, convenience, compliance, integrity and stability of the product.

Types of Packaging 

  • Primary packaging- is the material that first envelops the product and holds it. This is usually the smallest unit of distribution or use. Ex. Aerosol spray can, blister packs, bottles
Primary packaging

       Secondary packaging – the package external to primary package is known as secondary package, this package provides additional protection during warehousing and also provides information about drug product  ex. Boxes, cartons, leaflets

Secondary packaging

       Tertiary packaging – It is outer package of secondary packaging & prevents damage to the products. It is used for bulk handling & shipping.

Tertiary packaging

Characteristics of Packaging Material

       The material selected must have the following characteristics 

       Must meet tamper-resistance requirements

       Must be FDA approved

       Must be non-toxic

       Must not impart odor/taste to the product

        Must not reactive with the product

       They must protect the preparation from environmental conditions

Types of Packaging Materials Used For Pharmaceutical Packaging

Types of Packaging Materials Used For Pharmaceutical Packaging

GLASS

       Glass has been widely used as a drug packaging material.

       Glass is composed of sand, soda ash, limestone, & cullet.

       Si, Al, Na, K, Ca, Mg, Zn & Ba are generally used into preparation of glass.

Advantages

       They are hygienic and suitable for sterilization

       They are relatively non-reactive ( depending on the grade chosen)

•    It can accept a variety of closures

       They can be used on high speed packaging lines

        They are transparent.

       They have good protection power.

       They can be easily labeled.                                          

DISADVANTAGES

        It is relatively heavy

        Glass is fragile so easily broken.

        Release alkali to aqueous preparation

GLASS

Type of Glass

Type of Glass

       Type I—Highly resistant borosilicate glass

       Type II—Treated soda lime glass

        Type III—soda lime glass

       NP—soda glass (non parenteral usage)

Plastic

       Plastics may be defined as any group of substances, of natural or synthetic origins, consisting chiefly of polymers of high molecular weight that can be moulded into a shape or form by heat and pressure.

Advantages

       Less weight than glass,

       flexible

        Variety of sizes and shapes

       Essentially chemically inert, strong, rigid Safety use, high quality, various designs

       Extremely resistant to breakage                             

Disadvantages

       Absorption permeable to moisture

       Poor printing, thermostatic charge

Plastic

Types of plastic

Thermosetting

        When heated they may become flexible but they do not become liquid

        e.g. Urea-formaldehyde (UF), Phenol formaldehyde, Melamine formaldehyde (MF), Epoxy resins (epoxides), Polyurethanes (PURs)

Thermoplastics

        On heating they are softened to a viscous fluid which hardens again on cooling.

        2. e.g. Polyethylene{HDPE – LDPE}, Polyvinylchloride(PVC),Polystyrene Polypropylene, Nylon(PA), Polyethylene terephthalate(PET) ,Polyvinylidene chloride(PVdC), Polycarbonate Acrylonitrile butadiene styrene(ABS)

METALS

       Metals are used for the construction of containers. The metals commonly used for this purpose are aluminum, tin plated steel, stainless steel, tin, and lead

Advantages

       They are impermeable to light, moisture and gases.

       They are made into rigid unbreakable containers by impact extrusion.

       They are light in weight compared to glass containers.

       Labels can printed directly on to their surface

Disadvantages                                                

       They are expensive

       They react with certain chemicals

METALS

Types of Metals

Types of Metals

       Tin containers are preferred for food, pharmaceuticals and any product for which purity is considered.

       Tin is the most chemically inert of all collapsible metal tubes

       Lead has the lowest cost of all tube metals and is widely used for non-food products such as adhesives, inks. paints and lubricants.

       Lead should never be used alone for anything taken internally because of the risk lead poison

       With internal linings, lead tubes are used for products such as chloride tooth paste.

       Aluminium tubes offer significant savings in product shipping costs because of their light weight

       They are attractive in nature

RUBBER

       Rubber is used mainly for the construction of closure meant for vials, transfusion fluid bottles, dropping bottles and as washers in many other types of product

RUBBER

Types of Rubber

BUTYL RUBBER

Advantages:

        Permeability to water vapour .Water absorption is very low. They are relatively cheaper compared to other synthetic rubbers

Disadvantages:

          Slow decomposition takes place above 130 Degree C. Oil and solvent resistance is not very good

NITRILE RUBBER

Advantages:

        Oil resistant due to polar nitrile group. Heat resistant.

Disadvantages:

        Absorption of bactericide and leaching of extractives are considerable.

CHLOROPRENE RUBBERS

Advantages:

        Oil resistant. heat stability is good.

SILICON RUBBERS

Advantages:

        Heat resistance.Extremely low absorption and permeability of water. Excellent aging characteristic

Paper

       Paper and paper boards as packaging material are used to prepare containers as envelops for dispensing powders, a few tablets few capsules, etc. of as cartoons boxes and drums for storing large quantities of drugs in an industry.

       They are mostly used for secondary packaging and tertiary packaging

Paper
                 Biopharmaceutics PDF Notes

Leave a Comment