Drug used to control diarrhoea is called antidiarrheal
Mechanism of action
Antidiarrheals active opioids receptor in G.I. tract to decrease
intestinal motility and to increase the absorption of fluid and sodium in the
Drug example and doses
1 Loperamide – 2-4mg
2 Diphenoxylate – 5-10mg
3 Octreotide – 100-250mcg/TID
5 Bismuth subsalicylate – 60 ml 6hourly suspension
Indications / Uses
To treat underlying cause of diarrhea.
To control the relive symptoms of acute and chronic diarrhea.
Contraindication / Precautions
Contraindicated in abdominal pain of unknown pathology.
There is an increased risk of megacolon in clients with
inflammatory bowel disorders.
This could lead to a serious complication such as
perforation of bowel.
Pain at the injection site.
Gall stones. (With octreotide)
Drowsiness. (With diphenoxylate, and Lopramide
Use diphenoxylate or loperamide with similar acting drugs causes
additive anticholinergic effects.
Antidiarrheals Notes PDF