Proton pump inhibitors
These agents are used in patient with peptic ulcers (who
have failed to respond H2 Blocker).
Mechanism of Action
It acts by inhibiting proton pump which is final common step
in gastric acid secretion.
It also have antisecretory action.
Drug example and doses
1 Omeprazole – 20mg daily
2 Lansoprazole – 30 mg OD
3 Pantoprazole – 40mg
4 Rabeprazole – 20mg
Indications / Uses
Peptic ulcer.
Reflux esophagitis.
Zollinger – elision syndrome.
Prevent and treat NSAID’s related to gastric ulcer.
Contraindication / Precautions
Hypersensitivity.
Special precaution in pregnant and breast feeding mothers.
Adverse effects
Headache.
Abdominal pain.
Chest pain.
Diarrhea.
Dizziness.
Nausea / Vomiting.
Drug interactions
Proton pump inhibitor interfere with the absorption of drugs
(Ketoconazole, iron andampicillin) that’s depend on gastric PH absorption.
Proton pump inhibitors
