Chemical
incompatibility
q Chemical Incompatibility may be result of
chemical interactions between the ingredients of a prescription; as a result a
toxic or inactive product may be formed.
q It may be often occurs due to
·
Oxidation-reduction,
·
Acid-base
hydrolysis or combination reactions,
·
Double
decomposition reaction,
·
Complex
formation or pH change
q These reactions may be noticed by
·
Precipitation,
·
Effervescence,
·
Decomposition,
·
Colour
change
·
By
explosion.
q Chemical incompatibility may be intentional or
accidental.
- Precipitate yielding interactions
– Alkaloidal incompatibilities
– Soluble salicylates incompatibilities
- Incompatibility leading to carbon dioxide
evolution - Herapathite reaction
- Miscellaneous
Precipitate yielding interactions
q Generally it is observed that reactions between
solutions precede at faster rate produces precipitates which are indiffusible
in nature.
q These precipitates will thick and do not
diffuse readily.
q The reactions between dilute solutions proceed
slowly yielding a light diffusible precipitate.
q The precipitate so formed may be diffusible.
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