Chemical Incompatibility – PHARMACEUTICS II (Dispensing Pharmacy) D. Pharm 2nd year PDF Notes

 Chemical
incompatibility

q  Chemical Incompatibility may be result of
chemical interactions between the ingredients of a prescription; as a result a
toxic or inactive product may be formed.

q  It may be often occurs due to

·        
Oxidation-reduction,

·        
Acid-base
hydrolysis or combination reactions,

·        
Double
decomposition reaction,

·        
Complex
formation or pH change

q  These reactions may be noticed by

·        
Precipitation,

·        
Effervescence,

·        
Decomposition,

·        
Colour
change 

·        
By
explosion.

q  Chemical incompatibility may be intentional or
accidental.

  1. Precipitate yielding interactions

      Alkaloidal incompatibilities

      Soluble salicylates incompatibilities

  1. Incompatibility leading to carbon dioxide
    evolution

  2. Herapathite reaction

  3. Miscellaneous

Precipitate yielding interactions

q  Generally it is observed that reactions between
solutions precede at faster rate produces precipitates which are indiffusible
in nature.

q  These precipitates will thick and do not
diffuse readily.

q  The reactions between dilute solutions proceed
slowly yielding a light diffusible precipitate.

q  The precipitate so formed may be diffusible.

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