Suspensions are biphasic liquid dosage form consisting of finely divided solid particles dispersed in liquid medium with the help of suspending agent.
Components of Pharmaceutical Suspensions
- Active Ingredients: The therapeutic agents that form the core of the suspension.
- Suspension Vehicles: The liquid base that suspends the active ingredients.
- Stabilizers: Additives that prevent particle settling and maintain uniformity.
The requirements/characteristics for a good suspension
1. It should be chemically stable.
2. The sediment should be easily re-dispersed.
3. The suspension should be easily removed from the container.
4. The suspension should be free from large particles.
5. They should be resistant to micro – organisms.
6. Suspension for internal use must be palatable & suspension for external use should be force from gritty sealing.
Flocculated & De-flocculated suspension.
In flocculating system, when a suspending agent is added it should be well absorbed, due to the repulsive forces are low & the attractive forces are high. The individual particles are able to attract each other & form loose aggregates known as floccules.
This suspension is said to be flocculated.
In deflocculated system, when a suspending agent is added. The individual particles are dispersed with the aid of suspending agent. Due to the repulsive forces are high & the attractive forces are low. The individual particles are not able to attract each other. So the particles remain dispersed & do not aggregate. This suspension is said to be de-flocculated.
Differences between flocculated suspension and Deflocculated Suspension
|1. Particles from loose aggregate
|Particles exist in suspension as separate entity
|2. Rate of sedimentation is high
|Rate of sedimentation is low
|3. Sediment is formed rapidly
|Sediment is formed slowly
|4. The floccules stick to the sides of the container
|They do not stick to the sides of the container
|5.On shaking the sediment is easily
|On shaking the sediment is difficult to re-disperse
|6. The suspension has a pleasing appearance
|The suspension does not have a pleasing appearance
FAQs (Frequently Asked Questions)
- Are pharmaceutical suspensions safe for long-term use?
- Yes, when formulated and stored correctly, pharmaceutical suspensions are safe for long-term use.
- Can suspensions be administered to children and older adults?
- Absolutely, pharmaceutical suspensions are often preferred for pediatric and geriatric populations due to their ease of administration.
- Do all medications have suspension forms available?
- While not all medications are available in suspension form, a wide range of drugs can be formulated as suspensions.
- How do pharmaceutical suspensions contribute to environmental sustainability?
- Some pharmaceutical companies are adopting eco-friendly packaging for suspensions to reduce their environmental impact.
- Is it true that suspensions have a shorter shelf life compared to other dosage forms?
- Not necessarily. Properly formulated and stored suspensions can have a comparable shelf life to other dosage forms.
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