Applications of Instrumental methods in Pharmaceutical Analysis
Objectives
After this session,
students will be able to
• Enlist
the applications of Instrumental methods in Pharmaceutical Analysis
Applications
in Pharmaceutical Industry
• To
estimate the amount of drug in raw material to estimate its purity
• To
estimate the active pharmaceutical ingredients in formulation
• To
estimate individual components in formulations in presence of other ingredients
• To
identify molecules in research and development
Modern
Applications of Instrumental Methods of Analysis
• Genomics –
DNA sequencing and its related research. Genetic fingerprinting and DNA
microarray are important tools and research fields.
• Proteomics –
the analysis of protein concentrations and modifications
• Metabolomics –
similar to proteomics, but dealing with metabolites.
• Transcriptomics – mRNA and its associated field
• Lipidomics –
lipids and its associated field
• Peptidomics –
peptides and its associated field
• Metalomics –
similar to proteomics and metabolomics, but dealing with metal concentrations
binding to proteins and other molecules.
Applications in Pharmacy practice
• To
identify individual variation in dosage by bioavailability studies
• To
estimate the extent of Absorption
• To
estimate the extent of availability of the drug at the desired site of action
• To
estimate the extent of metabolism
• To
estimate the rate of elimination
• To
check the quality of incoming products in hospital supplies
• To
identify medication errors
Summary
• Instrumental
Methods of Analysis find place in every aspect of Pharmaceutical production and
product development which involves clinical studies and also in routine
clinical usage to monitor patient’s response to treatment
• Good
Laboratory Practices and Good Manufacturing Practices are to be adopted for
high quality of medicines
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